Rabbit IgG polyclonal antibody for Calcium/calmodulin-dependent protein kinase kinase 1(CAMKK1) detection. Tested with WB, IHC in Human;Mouse;Rat.-Rabbit IgG polyclonal antibody for Calcium/calmodulin-dependent protein kinase kinase 1(CAMKK1) detection. Tested with WB, IHC in Human;Mouse;Rat.代理/參數(shù)/廠家-一抗-艾美捷科技有限公司

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中文名稱: Rabbit IgG polyclonal antibody for Calcium/calmodulin-dependent protein kinase kinase 1(CAMKK1) detection. Tested with WB, IHC in Human;Mouse;Rat.

英文名字: Rabbit IgG polyclonal antibody for Calcium/calmodulin-dependent protein kinase kinase 1(CAMKK1) detection. Tested with WB, IHC in Human;Mouse;Rat.

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背景資料: CAMKK1, Calcium/calmodulin-dependent protein kinase kinase 1 is an enzyme that in humans is encoded by the CAMKK1 gene. The CAMKK1 gene is mapped to chromosome 17. The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent(CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene.Camkk1binds calmodulin and activated Camk4 with a 6-fold increase in total activity and a 100-fold increase in Camk4 Ca(2+)-independent activity. Camkk1 catalyzed a 10-fold increase in the total activity of Camk1 and had no effect on Camk2. Cotransfection of COS-7 cells with Camkk1 and Camk4 resulted in a 14-fold increase in CRE-binding protein-dependent transcription compared with Camk4 alone, suggesting that Camkk1 enhances Camk4-mediated transcriptional regulation.

免疫原: A synthetic peptide corresponding to a sequence at the N-terminus of mouse CaMKK(10-31aa QDPRAELVDRVAAINVAHLEEA), different from the related human sequence by three amino acids, and from the related rat sequence by two amino acids.

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