Rabbit IgG polyclonal antibody for Beclin-1(BECN1) detection. Tested with WB, IHC, ICC/IF, FCM in Human;Mouse;Rat.-Rabbit IgG polyclonal antibody for Beclin-1(BECN1) detection. Tested with WB, IHC, ICC/IF, FCM in Human;Mouse;Rat.代理/參數(shù)/廠家-一抗-艾美捷科技有限公司

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中文名稱: Rabbit IgG polyclonal antibody for Beclin-1(BECN1) detection. Tested with WB, IHC, ICC/IF, FCM in Human;Mouse;Rat.

英文名字: Rabbit IgG polyclonal antibody for Beclin-1(BECN1) detection. Tested with WB, IHC, ICC/IF, FCM in Human;Mouse;Rat.

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背景資料: Beclin-1, also known as also known as ATG6 or VPS30 is a protein that in humans is encoded by the BECN1 gene. Beclin-1 and its binding partner class III phosphoinositide 3-kinase (PI3K), also named Vps34, are required for the initiation of the formation of the autophagosome in autophagy. This gene participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration. Schizophrenia is associated with low levels of Beclin-1 in the hippocampus of the affected which causes diminished autophagywhich in turn results in increased neuronal cell death. It has been found that beclin-1 can promote autophagy in autophagy-defective yeast with a targeted disruption of apg6/vps30, and in human MCF7 breast carcinoma cells.

免疫原: E.coli-derived human Beclin 1 recombinant protein (Position: M1-S354). Human Beclin 1 shares 97% amino acid (aa) sequence identity with both mouse and rat Beclin 1.

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