Mouse IgG monoclonal antibody for alpha 1 Catenin/CTNNA1 detection. Tested with WB, IHC, FCM in Human;Mouse;Rat.-Mouse IgG monoclonal antibody for alpha 1 Catenin/CTNNA1 detection. Tested with WB, IHC, FCM in Human;Mouse;Rat.代理/參數(shù)/廠家-一抗-艾美捷科技有限公司

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中文名稱: Mouse IgG monoclonal antibody for alpha 1 Catenin/CTNNA1 detection. Tested with WB, IHC, FCM in Human;Mouse;Rat.

英文名字: Mouse IgG monoclonal antibody for alpha 1 Catenin/CTNNA1 detection. Tested with WB, IHC, FCM in Human;Mouse;Rat.

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背景資料: CTNNA1, also known as Catenin alpha-1 or Catenin (cadherin-associated protein), alpha 1, is a protein that in humans is encoded by the CTNNA1 gene. It is mapped to 5q31.2. When surface epithelium CTNNA1 was ablated, hair follicle development was blocked and epidermal morphogenesis was dramatically affected, with defects in adherens junction formation, intercellular adhesion, and epithelial polarity. In vitro, CTNNA1 null keratinocytes were poorly contact inhibited and grew rapidly. These differences were not dependent upon intercellular adhesion and were in marked contrast to keratinocytes conditionally null for another essential intercellular adhesion protein, desmoplakin Knockout keratinocytes exhibited sustained activation of the Ras-MAPK cascade due to aberrations in growth factor responses. It is concluded that features of precancerous lesions often attributed to defects in cell cycle regulatory genes can be generated by compromising the function of CTNNA1.

免疫原: E.coli-derived human CTNNA1 recombinant protein (Position: D143-D292). Human CTNNA1 shares 98% amino acid (aa) sequence identity with mouse CTNNA1.

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