Ataxin-2, the protein encoded by the ATXN2 gene, contains a polyglutamine tract, long expansions(greater than 33 repeats) of which result in spinocerebellar ataxia-2(SCA2), an autosomal dominant form of olivopontocerebellar atrophy. The gene for spinocerebellar ataxia type 2(SCA2) has been mapped to 12q24.1. Ataxin-2 associates with L- and T-plastin and that overexpression of ataxin-2 leads to accumulation of T-plastin in mammalian cells.
應用類型
FC,ICC,IHC,WB
免疫原
A synthetic peptide corresponding to a sequence at the C-terminus of human ATX2(1293-1313aa TTAHFPYMTHPSVQAHHQQQL), identical to the related mouse sequence.