用于開發(fā)夾心ELISA試劑盒以測量細(xì)胞培養(yǎng)上清液、血清和血漿（肝素、EDTA）中的大鼠FGF21。-For the development of sandwich ELISA kit to measure rat FGF21 in cell culture supernatants, serum and plasma (heparin, EDTA).代理/參數(shù)/廠家-ELISA試劑盒-艾美捷科技有限公司

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英文名字: For the development of sandwich ELISA kit to measure rat FGF21 in cell culture supernatants, serum and plasma (heparin, EDTA).

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背景資料: Fibroblast growth factor 21 is a protein that in humans is encoded by the FGF21 gene. By genomic sequence analysis, Nishimura et al.(2000) identified the FGF21 gene within the 5-prime flanking region of the FUT1 gene on chromosome 19. The protein encoded by this gene is a member of the fibroblast growth factor(FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF21 stimulates glucose uptake in adipocytes but not in other cell types. This effect is additive to the activity of insulin. FGF21 treatment of adipocytes is associated with phosphorylation of FRS2, a protein linking FGF receptors to the Ras/MAP kinase pathway. FGF21 injection in ob/ob mice results in an increase in Glut1 in adipose tissue. FGF21 also protects animals from diet-induced obesity when overexpressed in transgenic mice and lowers blood glucose and triglyceride levels when administered to diabetic rodents.

產(chǎn)品描述: 成纖維細(xì)胞生長因子21是一種在人體中由FGF21基因編碼的蛋白質(zhì)。通過基因組序列分析，Nishimura等人（2000）鑒定了FGF21基因位于染色體19上FUT1基因的5引物側(cè)翼區(qū)域內(nèi)。該基因編碼的蛋白質(zhì)是成纖維細(xì)胞生長因子（FGF）家族的成員。FGF家族成員具有廣泛的促有絲分裂和細(xì)胞存活活性，并參與多種生物學(xué)過程，包括胚胎發(fā)育、細(xì)胞生長、形態(tài)發(fā)生、組織修復(fù)、腫瘤生長和侵襲。FGF21刺激脂肪細(xì)胞中的葡萄糖攝取，但不刺激其他類型的細(xì)胞。這種作用是胰島素活性的附加作用。脂肪細(xì)胞的FGF21處理與FRS2的磷酸化有關(guān)，F(xiàn)RS2是一種連接FGF受體和Ras/MAP激酶途徑的蛋白質(zhì)。在ob/ob小鼠中注射FGF21導(dǎo)致脂肪組織中Glut1的增加。當(dāng)FGF21在轉(zhuǎn)基因小鼠中過表達(dá)時(shí)，F(xiàn)GF21還保護(hù)動(dòng)物免于飲食誘導(dǎo)的肥胖，并且當(dāng)給予糖尿病嚙齒動(dòng)物時(shí)，F(xiàn)GF21降低血糖和甘油三酯水平。

其他: Nordic BioSite(北歐生物) 總部位于瑞典，成立于1997年，旨在分銷研究和診斷領(lǐng)域的高質(zhì)量和創(chuàng)新產(chǎn)品。 Nordic BioSite 被公認(rèn)為整個(gè)北歐生物醫(yī)學(xué)研究和診斷產(chǎn)品領(lǐng)域的領(lǐng)導(dǎo)者。他們擁有超過570萬種的產(chǎn)品組合，代理了遍布?xì)W洲和美國的頂級生物試劑制造商，是歐洲知名的一站式生物試劑代理商。除了作為分銷商之外，Nordic BioSite 還擁有不斷增長的自產(chǎn)產(chǎn)品線——BioSite mAb、BioSite ELISA、BioSite Flow、Optibodies和 BioSite Protein, 目前艾美捷代理的是Nordic BioSite自產(chǎn)產(chǎn)品線(共26W+產(chǎn)品)。Nordic BioSite的產(chǎn)品類型主要是抗體，蛋白和試劑盒，產(chǎn)品適用范圍涵蓋15個(gè)不同的物種(人，牛，犬，鯰魚，雞，海豚，馬，貓，豚鼠，小鼠，綿羊，兔子，大鼠，豬和火雞)，可為您提供一站式的生命科學(xué)研究解決方案~