Endothelial protein C receptor(EPCR) also known as CCCA or PROCR is a protein that in humans is encoded by the PROCR gene. PRPCR gene is mapped to 20q11.2 by radiation hybrid analysis and FISH. The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy.
產(chǎn)品描述
內(nèi)皮蛋白C受體(英語(yǔ):Endothelial protein C receptor,EPCR)也稱(chēng)為CCCA或PROCR,是一種由人類(lèi)PROCR基因編碼的蛋白質(zhì)。利用輻射雜交和FISH技術(shù)將PRPCR基因定位于20q11.2。該基因編碼的蛋白質(zhì)是活化蛋白C的受體,活化蛋白C是一種由凝血途徑活化并參與凝血途徑的絲氨酸蛋白酶。編碼的蛋白質(zhì)是N-糖基化的I型膜蛋白,其增強(qiáng)蛋白C的活化。該基因的突變與靜脈血栓栓塞和心肌梗死以及妊娠期晚期胎兒丟失有關(guān)。