- 中文名稱
用于開發(fā)夾心ELISA試劑盒以測定細胞培養(yǎng)上清液、血清和血漿(肝素、EDTA)中的小鼠TFF1。
- 英文名字
- For the development of sandwich ELISA kit to measure mouse TFF1 in cell culture supernatants, serum and plasma (heparin, EDTA).
- 供應商
- Nordic BioSite
- 產品貨號
- NDC-KBB-AFC98Z-5
- 產品報價
- ¥詢價/5plates

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- 產品新聞

- 背景資料
- TFF1(Trefoil factor 1), also known as pS2, is a protein that in humans is encoded by the TFF1 gene. Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. It is found that TFF1 in normal human urine inhibited the growth of calcium oxalate crystals. Urinary TFF1 showed an inhibitory potency similar to that of nephrocalcin, and inhibition was dose dependent and inhibited by TFF1 antisera, particularly by antisera directed to the TFF1 C terminus. Concentrations and relative amounts of TFF1 in the urine of patients with idiopathic calcium oxalate kidney stones were significantly less than those found in controls. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.
- 產品描述
- TFF1(三葉因子1),也稱為pS2,是一種在人類中由TFF1基因編碼的蛋白質。三葉草家族成員的特征在于具有至少一個拷貝的三葉草基序,即含有三個保守二硫鍵的40個氨基酸的結構域。是在胃腸道粘膜表達的穩(wěn)定分泌蛋白。其功能尚不明確,但可保護粘膜免受損傷、穩(wěn)定粘液層并影響上皮愈合。結果表明,正常人尿中TFF1對草酸鈣晶體生長有抑制作用。尿TFF1顯示出與腎鈣蛋白相似的抑制效力,并且抑制是劑量依賴性的,并且被TFF1抗血清抑制,特別是被針對TFF1C末端的抗血清抑制。特發(fā)性草酸鈣腎結石患者尿液中TFF1的濃度和相對含量顯著低于對照組。該基因在胃粘膜中表達,由于其在人腫瘤中的表達也已被研究。該基因和其他兩個相關的三葉草家族成員基因被發(fā)現(xiàn)在21號染色體上的一個簇中。
- 產品特點
- 人可替寧ELISA試劑盒(競爭性EIA)
- 保存建議
- -20°C
- 其他
- Nordic BioSite(北歐生物) 總部位于瑞典,成立于1997年,旨在分銷研究和診斷領域的高質量和創(chuàng)新產品。 Nordic BioSite 被公認為整個北歐生物醫(yī)學研究和診斷產品領域的領導者。他們擁有超過570萬種的產品組合,代理了遍布歐洲和美國的頂級生物試劑制造商,是歐洲知名的一站式生物試劑代理商。除了作為分銷商之外,Nordic BioSite 還擁有不斷增長的自產產品線——BioSite mAb、BioSite ELISA、BioSite Flow、Optibodies和 BioSite Protein, 目前艾美捷代理的是Nordic BioSite自產產品線(共26W+產品)。Nordic BioSite的產品類型主要是抗體,蛋白和試劑盒,產品適用范圍涵蓋15個不同的物種(人,牛,犬,鯰魚,雞,海豚,馬,貓,豚鼠,小鼠,綿羊,兔子,大鼠,豬和火雞),可為您提供一站式的生命科學研究解決方案~
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