用于開發(fā)夾心ELISA試劑盒，以測定細(xì)胞培養(yǎng)上清液、細(xì)胞裂解物、血清和血漿（肝素、EDTA、檸檬酸鹽）中的小鼠BDNF。-For the development of sandwich ELISA kit to measure mouse BDNF in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA, citrate).代理/參數(shù)/廠家-ELISA試劑盒-艾美捷科技有限公司

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中文名稱: 用于開發(fā)夾心ELISA試劑盒，以測定細(xì)胞培養(yǎng)上清液、細(xì)胞裂解物、血清和血漿（肝素、EDTA、檸檬酸鹽）中的小鼠BDNF。

英文名字: For the development of sandwich ELISA kit to measure mouse BDNF in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA, citrate).

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背景資料: Brain-derived neurotrophic factor(BDNF) is a prosurvival factor induced by cortical neurons that is necessary for survival of striatal neurons in the brain. It is a secreted protein with the molecular weight of 27.8kDa, consisting of 247 amino acids. It is known to promote neuronal survival and differentiation. BDNF shares substantial amino acid sequence identity with nerve growth factor(NGF). BDNF and neurotrophin-3(NT-3) are two recently cloned neurotrophic factors that are homologous to NGF. mRNA products of the BDNF and NT-3 genes are detected in the adult human brain, suggesting that these proteins are involved in the maintenance of the adult nervous system. BDNF and other neurotrophins are critically involved in long-term potentiation(LTP). BDNF-mediated LTP is induced postsynaptically. BDNF has trophic effects on serotonergic(5-HT) neurons in the central nervous system. BDNF has an essential maintenance function in the regulation of anxiety-related behavior and in food intake through central mediators in both the basal and fasted state. It plays a role in treating breathing disorders such as respiratory insufficiency after spinal injury.

產(chǎn)品描述: 腦源性神經(jīng)營養(yǎng)因子（BDNF）是一種由皮層神經(jīng)元誘導(dǎo)的促存活因子，是紋狀體神經(jīng)元在腦中存活所必需的。它是一種分泌性蛋白，分子量為27.8kDa，由247個氨基酸組成。已知其促進(jìn)神經(jīng)元存活和分化。BDNF與神經(jīng)生長因子（NGF）具有基本相同的氨基酸序列。BDNF和神經(jīng)營養(yǎng)因子-3（neurotrophin-3，NT-3）是最近克隆的兩種與NGF同源的神經(jīng)營養(yǎng)因子。在成人腦中檢測到BDNF和NT-3基因的mRNA產(chǎn)物，表明這些蛋白質(zhì)參與成人神經(jīng)系統(tǒng)的維持。BDNF和其他神經(jīng)營養(yǎng)因子在長時程增強（LTP）中起關(guān)鍵作用。BDNF介導(dǎo)的LTP是突觸后誘導(dǎo)的。BDNF對中樞神經(jīng)系統(tǒng)中的5-HT神經(jīng)元具有營養(yǎng)作用。BDNF在基礎(chǔ)狀態(tài)和禁食狀態(tài)下通過中樞介質(zhì)調(diào)節(jié)焦慮相關(guān)行為和食物攝入中具有重要的維持功能。它在治療脊柱損傷后呼吸功能不全等呼吸障礙中發(fā)揮作用。

其他: Nordic BioSite(北歐生物) 總部位于瑞典，成立于1997年，旨在分銷研究和診斷領(lǐng)域的高質(zhì)量和創(chuàng)新產(chǎn)品。 Nordic BioSite 被公認(rèn)為整個北歐生物醫(yī)學(xué)研究和診斷產(chǎn)品領(lǐng)域的領(lǐng)導(dǎo)者。他們擁有超過570萬種的產(chǎn)品組合，代理了遍布?xì)W洲和美國的頂級生物試劑制造商，是歐洲知名的一站式生物試劑代理商。除了作為分銷商之外，Nordic BioSite 還擁有不斷增長的自產(chǎn)產(chǎn)品線——BioSite mAb、BioSite ELISA、BioSite Flow、Optibodies和 BioSite Protein, 目前艾美捷代理的是Nordic BioSite自產(chǎn)產(chǎn)品線(共26W+產(chǎn)品)。Nordic BioSite的產(chǎn)品類型主要是抗體，蛋白和試劑盒，產(chǎn)品適用范圍涵蓋15個不同的物種(人，牛，犬，鯰魚，雞，海豚，馬，貓，豚鼠，小鼠，綿羊，兔子，大鼠，豬和火雞)，可為您提供一站式的生命科學(xué)研究解決方案~