MethylFlash Global DNA Hydroxymethylation (5-hmC) ELISA Easy Kit(P-1032)是經(jīng)過全新優(yōu)化的、完整的的試劑組合,可以利用抗體結(jié)合和ELISA原理方式,定量分析DNA中5-hmc。它可以直接檢測哺乳動物,植物,真菌細(xì)菌,病毒,細(xì)胞,組織,血清/血漿以及其它體液中的總DNA樣本的5-hmc的甲基化程度。
已發(fā)表的部分文獻(xiàn): 標(biāo)題:Downregulation of Methyltransferase Dnmt2 Results in Condition-dependent Telomere Shortening and Senescence or Apoptosis in Mouse Fibroblasts.作者:Lewinska A, Adamczyk-Grochala J, Kwasniewicz E, Wnuk M;雜志名稱:J Cell Physiol 標(biāo)題:Perinatal high fat diet and early life methyl donor supplementation alter one carbon metabolism and DNA methylation in the brain.作者:McKee SE, Zhang S, Chen L, Rabinowitz JD, Reyes TM;雜志名稱:J Neurochem 標(biāo)題:EZH2 Methyltransferase Activity Controls Pten Expression and mTOR Signaling During Fear Memory Reconsolidation.作者:Jarome TJ, Perez GA, Hauser RM, Hatch KM, Lubin FD;雜志名稱:J Neurosci 標(biāo)題:Early-life epigenetic changes along the corticotropin-releasing hormone (CRH) gene influence resilience or vulnerability to heat stress later in life.作者:Cramer T, Rosenberg T, Kisliouk T, Meiri N;雜志名稱:Mol Psychiatry 標(biāo)題:PARP Inhibitor Affects Long-term Heat-stress Response via Changes in DNA Methylation.作者:Cramer T, Rosenberg T, Kisliouk T, Meiri N;雜志名稱:Neuroscience 標(biāo)題:IDH3?± regulates one-carbon metabolism in glioblastoma.作者:May JL, Kouri FM, Hurley LA, Liu J, Tommasini-Ghelfi S, Ji Y, Gao P, Calvert AE, Lee A, Chandel NS, Davuluri RV, Horbinski CM, Locasale JW, Stegh AH;雜志名稱:Sci Adv 標(biāo)題:Decreased Nuclear Ascorbate Accumulation Accompanied with Altered Genomic Methylation Pattern in Fibroblasts from Arterial Tortuosity Syndrome Patients.作者:N??meth CE, Nemoda Z, L?‘w P, Szab?3 P, Horv??th EZ, Willaert A, Boel A, Callewaert BL, Coucke PJ, Colombi M, B??nhegyi G, Margittai ?‰;雜志名稱:Oxid Med Cell Longev 標(biāo)題:Genome-wide DNA methylation and hydroxymethylation analysis reveal human menstrual blood-derived stem cells inhibit hepatocellular carcinoma growth through oncogenic pathway suppression via regulating 5-hmC in enhancer elements.作者:Wu Y, Chen X, Zhao Y, Wang Y, Li Y, Xiang C;雜志名稱:Stem Cell Res Ther Epigentek 公司是全球領(lǐng)先的表觀遺傳學(xué)相關(guān)研究的技術(shù)創(chuàng)新者和產(chǎn)品開發(fā)供應(yīng)商。開發(fā)了超過700多個專利產(chǎn)品,為表觀遺傳學(xué)方面的研究和新藥研發(fā)提供全面系統(tǒng)的解決方案,涵蓋樣品制備、DNA/RNA甲基化(5-mc, 5-hmc, 5-fc, m6A)/DNMT分析、ChIP、組蛋白甲基化/乙酰化/去乙酰化/磷酸化/SUMO-等領(lǐng)域,提供小分子抑制劑、蛋白質(zhì)、抗體、以及分析試劑盒產(chǎn)品。