T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane domain-containing protein 3 (VSTM3),which belongs to single-pass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
序列
提供的Human CellExp?TIGIT,大鼠重組Human CellExp? TIGIT, rat recombinant是Biovision品牌中國(guó)區(qū)域總代理艾美捷科技產(chǎn)品,具體的蛋白序列可查看提供的英文版本產(chǎn)品說(shuō)明書(shū)。
來(lái)源宿主
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溶解建議
Reconstitute in sterile deionized water to a concentration of 50 μg/ml.