Kinase insert domain receptor (KDR) is also known as CD309, FLK1, VEGFR, VEGFR2, and is one of the subtypes of VEGFR. VEGF receptors are receptors for vascular endothelial growth factor (VEGF). The VEGF receptors have an extracellular portion consisting of 7 immunoglobulin-like domains, a single transmembrane spanning region and an intracellular portion containing a split tyrosine-kinase domain. VEGF-A binds to VEGFR-1 (Flt-1) and VEGFR-2 (KDR/Flk-1). VEGFR-2 appears to mediate almost all of the known cellular responses to VEGF.The function of VEGFR-1 is less well defined, although it is thought to modulate VEGFR-2 signaling. Another function of VEGFR-1 may be to act as a dummy/decoy receptor, sequestering VEGF from VEGFR-2 binding (this appears to be particularly important during vasculogenesis in the embryo). In addition, VEGFR2 is able to interact with HIV-1 extracellular Tat protein upon VEGF activation, and seems to enhance angiogenesis in Kaposi's sarcoma lesions.
序列
提供的人CellExp?VEGF R2 / KDR,F(xiàn)c標簽小鼠重組Human CellExp? VEGF R2 / KDR, Fc Tag Mouse Recombinant 是Biovision品牌中國區(qū)域總代理艾美捷科技產(chǎn)品,具體的蛋白序列可查看提供的英文版本產(chǎn)品說明書。
來源宿主
提供的人CellExp?VEGF R2 / KDR,F(xiàn)c標簽小鼠重組Human CellExp? VEGF R2 / KDR, Fc Tag Mouse Recombinant 產(chǎn)品來源宿主,查看該產(chǎn)品說明書,或者在線咨詢我們。
溶解建議
Centrifuge the vial prior to opening. Reconstitute in sterile deionized water.