MAPK14 belongs to the MAP kinase family and is most associated with p38 MAP kinases(MAPKs). MAPKs are activated mainly as a reaction to cellular stress and inflammatory cytokines, and inhibitors that target the MAPK14 and MAPK11 have demonstrated ability to cure inflammatory disease. The substrates of this kinase contain transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which demonstrate the parts of MAPK14 in stress-related transcription, cell cycle regulation and genotoxic stress response.
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來(lái)源宿主
大腸桿菌中重組表達(dá).
溶解建議
提供的重組人促分裂原活化蛋白激酶14產(chǎn)品形式為無(wú)菌的無(wú)色溶液.
保存建議
建議將重組人促分裂原活化蛋白激酶14產(chǎn)品整瓶保存于4℃可保存2-4周. 長(zhǎng)期保存,請(qǐng)置于-20℃.長(zhǎng)期保存,推薦添加載體蛋白 (0.1% HSA or BSA).請(qǐng)避免反復(fù)凍融.