Mitogen-activated protein kinase 9 (MAPK9) belongs to the MAP kinase family. MAP kinases function as an integration point for numerous biochemical signals, and are involved in a broad variety of cellular processes such as proliferation, differentiation, transcription regulation and development. MAPK9 targets specific transcription factors, and consequently mediates immediate-early gene expression in response to diverse cell stimuli. As an active dimer, MAPK9 can translocate to the nucleus and control transcription through its effects on c-Jun, ATF-2, and other transcription factors. MAPK9 blocks the ubiquitination of tumor suppressor p53, and so it increases the stability of p53 in nonstressed cells.
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大腸桿菌中重組表達(dá).
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保存建議
建議將重組人促分裂原活化蛋白激酶9產(chǎn)品整瓶保存于4℃可保存2-4周. 長期保存,請置于-20℃.長期保存,推薦添加載體蛋白 (0.1% HSA or BSA).請避免反復(fù)凍融.