The Casein kinase 2 (EC2.7.11.1) is a serine/threonine-selective protein kinasethat is a tetramer of two alpha subunits and two beta subunits. The alpha subunits have the catalytic kinase domain. Casein kinase 2 has been implicated in cell cyclecontrol, DNA repair, regulation of the circadian rhythmand other cellular processes.
Casein kinase 2 activity has been reported to be activated following Wnt signaling pathwayactivation. A Pertussis toxin-sensitive G proteinand Disheveled appear to be an intermediary between Wnt-mediated activation of the Frizzled receptor and activation of casein kinase 2.
Mice that lack casein kinase 2 alpha prime have a defect in the morphology of developing sperm.
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來源宿主
大腸桿菌中重組表達(dá)
溶解建議
提供的人酪蛋白激酶2a,His標(biāo)簽(CSNK2A1 His)產(chǎn)品為過濾滅菌的透明溶液;其中人酪蛋白激酶2a,His標(biāo)簽(CSNK2A1 His)產(chǎn)品溶解于20mM Tris pH 8.0 ,500mM NaCl,1mM DTT,50%甘油溶液中.