【FGFR2】重組人成纖維細胞生長因子受體-2-Recombinant Human Fibroblast Growth Factor Receptor-2代理/參數/廠家-蛋白標準品-艾美捷科技有限公司

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背景資料: Fibroblast Growth Factors （FGFs） comprise a family of at least eighteen structurally realted proteins that are involved in a multitude of physiological and pathological cellular processes， including cell growth， differentation， angiogenesis， wound healing and tumorgenesis. The biological activities of the FGFs are mediated by a family if type I transmembrane tyrosine kinases which undergo dimerization and autophosphorylation after ligand binding. Four distinct genes encoding closely related FGF receptors， FGFR-1to -4 are known. Multiple forms of FGFR-1 to -3 are generated by alternative splicing of the mRNAs. A frequent splicing event involving FGFR-1 and -2 results in receptors containing all three Ig domains， referred to as the alpha isoform， or only IgII and IgIII， referred to as the ? isoform. Only the alpha isoform has been identified for FGFR-3 and FGFR-4. Additional splicing events for FGFR-1 to -3， involving the C-terminal half of the IgIII domain encoded by two mutually exclusive alternative exons， generate FGF receptors with alternative IgIII domains （IIIb and IIIc）. A IIIa isoform which is a secreted FGF binding protein containing only the N-terminal half of the IgIII domain plus some intron sequences has also been reported for FGFR-1. Mutations in FGFR-1 to -3 have been found in patients with birth defects involving craniosynostosis.

溶解建議: 提供的人成纖維細胞生長因子受體-2（FGFR2）產品為過濾滅菌的白色凍干粉末；該凍干粉末是從含1mg/ml人成纖維細胞生長因子受體-2（FGFR2）的溶液（不含添加劑）中過濾滅菌并凍干產生的.我們建議加無菌的PBS以配制工作儲存液到不低于100ug/ml，后繼實驗過程中可根據實驗要求進一步稀釋.

保存建議: 人成纖維細胞生長因子受體-2（FGFR2）凍干粉末在室溫可保存3周，或置于-18℃凍存用于長期保存.重新溶解后可以在4℃冷藏保存至少2-7天以上；如果想延長保存時間，建議分裝（加載體蛋白如0.1% HSA或 BSA）后置于-18℃凍存.請避免反復凍融.

其他: ProSpec 是一家全球著名細胞因子蛋白生產和研發(fā)的公司，具有20多年的生產經驗，專注于蛋白（重組及合成）生產研發(fā)。我們的核心產品包括：干擾素、白介素、骨蛋白、腫瘤壞死因子、成纖維生長因子、瘦素、干細胞因子、催乳素、表皮生長因子、胰島素樣生長因子、神經生長因子、集落刺激因子、激素、酶、病毒抗原以及各種重組蛋白等。領先的生產工藝和規(guī)模使其可以提供毫克到克級蛋白，價格優(yōu)于同類公司。絕大部分產品是天然成熟型蛋白，而不含有標簽蛋白。考慮到大部分研究者希望能更靈活地配制蛋白溶液，ProSpec-Tany絕大部分產品沒有添加保護劑或鹽，這就對工藝提出了更高的要求。同時，ProSpec-Tany絕大部分產品為凍干粉，因此易于運輸和保存。