中文名稱

【FGFR4】重組人成纖維細(xì)胞生長因子受體-4

英文名字

Recombinant Human Fibroblast Growth Factor Receptor-4

供應(yīng)商

ProSpec

產(chǎn)品貨號

PKA-233

產(chǎn)品報價

￥詢價/10ug   ￥1mg   ￥2ug

產(chǎn)品說明書

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購買方式

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產(chǎn)品新聞

背景資料

Fibroblast growth factors （FGFs） comprise a family of at least eighteen structurally related proteins that are involved in a multitude of physiological and pathological cellular processes， including cell growth， differentiation， angiogenesis， wound healing and tumorgenesis. The biological activities of the FGFs are mediated by a family of type I transmembrane tyrosine kinases which undergo dimerization and autophosphorylation after ligand binding. Four distinct genes encoding closely related FGF receptors， FGF R1 - 4， are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide， three immunoglobulin （Ig）-like domains， an acid-box region containing a run of acidic residues between the IgI and IgII domains， a transmembrane domain and the split tyrosine-kinase domain. Multiple forms of FGF R1 - 3 are generated by alternative splicing of the mRNAs. A frequent splicing event involving FGF R1 and 2 results in receptors containing all three Ig domains， referred to as the a isoform， or only IgII and IgIII， referred to as the b isoform. Only the a isoform has been identified for FGF R3 and FGF R4. Additional splicing events for FGF R1 - 3， involving the C-terminal half of the IgIII domain encoded by two mutually exclusive alternative exons， generate FGF receptors with alternative IgIII domains （IIIb and IIIc）. A IIIa isoform which is a secreted FGF binding protein containing only the N-terminal half of the IgIII domain plus some intron sequences has also been reported for FGF R1. Mutations in FGF R1 - 3 have been found in patients with birth defects involving craniosynostosis. The complex patterns of expression of these receptors as well as the specificity of their interactions with the various FGF ligand family members are under investigation.

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來源宿主

昆蟲細(xì)胞中重組表達(dá)

溶解建議

提供的人成纖維細(xì)胞生長因子受體-4（FGFR4）產(chǎn)品為過濾滅菌的白色凍干粉末；該凍干粉末是從含1mg/ml人成纖維細(xì)胞生長因子受體-4（FGFR4）的溶液（不含添加劑）中過濾滅菌并凍干產(chǎn)生的.我們建議加無菌的PBS以配制工作儲存液到不低于100ug/ml，后繼實驗過程中可根據(jù)實驗要求進一步稀釋.

保存建議

人成纖維細(xì)胞生長因子受體-4（FGFR4）凍干粉末在室溫可保存3周，或置于-18℃凍存用于長期保存.重新溶解后可以在4℃冷藏保存至少2-7天以上；如果想延長保存時間，建議分裝（加載體蛋白如0.1% HSA或 BSA）后置于-18℃凍存.請避免反復(fù)凍融.

其他

ProSpec 是一家全球著名細(xì)胞因子蛋白生產(chǎn)和研發(fā)的公司，具有20多年的生產(chǎn)經(jīng)驗，專注于蛋白（重組及合成）生產(chǎn)研發(fā)。我們的核心產(chǎn)品包括：干擾素、白介素、骨蛋白、腫瘤壞死因子、成纖維生長因子、瘦素、干細(xì)胞因子、催乳素、表皮生長因子、胰島素樣生長因子、神經(jīng)生長因子、集落刺激因子、激素、酶、病毒抗原以及各種重組蛋白等。 領(lǐng)先的生產(chǎn)工藝和規(guī)模使其可以提供毫克到克級蛋白，價格優(yōu)于同類公司。絕大部分產(chǎn)品是天然成熟型蛋白，而不含有標(biāo)簽蛋白。考慮到大部分研究者希望能更靈活地配制蛋白溶液，ProSpec-Tany絕大部分產(chǎn)品沒有添加保護劑或鹽，這就對工藝提出了更高的要求。同時，ProSpec-Tany絕大部分產(chǎn)品為凍干粉，因此易于運輸和保存。

注意

該頁面的中文產(chǎn)品信息的翻譯，僅供參考。準(zhǔn)確的產(chǎn)品信息請以廠家的英文說明書為準(zhǔn)。下單前，請瀏覽說明書確認(rèn)。

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