TPMT, thiopurine S-methyltransferase, is a cytosolic enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. TPMT activity exhibits autosomal codominant genetic polymorphism, and patients inheriting TPMT-deficiency are at high risk of potentially fatal hematopoietic toxicity.
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來源宿主
大腸桿菌中重組表達(dá)
溶解建議
提供的人硫嘌呤甲基轉(zhuǎn)移酶(TPMT)產(chǎn)品為過濾滅菌的無色溶液;其中1mg/ml人硫嘌呤甲基轉(zhuǎn)移酶(TPMT)產(chǎn)品溶解于20mM Tris 8.0,0.2mM PMSF,2mM EDTA溶液中.