ATF3 belongs to the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. ATF3 binds the cAMP response element (CRE) (consensus: 5’-GTGACGT[AC][AG]-3’), a sequence present in numerous viral and cellular promoters. Multiple transcript variants encoding two different isoforms are known for this gene. The longer isoform represses transcription from promoters with ATF binding elements instead of activating it. The shorter isoform (deltaZip2) which stimulates transcription by sequestering inhibitory co-factors away from the promoter has no leucine zipper protein-dimerization motif and does not bind to DNA.
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大腸桿菌中重組表達.
溶解建議
提供的重組人活化轉錄因子3產(chǎn)品形式為無菌的澄清溶液.
保存建議
建議將重組人活化轉錄因子3產(chǎn)品整瓶保存于4℃可保存2-4周. 長期保存,請置于-20℃.長期保存,推薦添加載體蛋白 (0.1% HSA or BSA).請避免反復凍融.