【ILK1】重組人整合素連接激酶-Recombinant Human Integrin Linked Kinase代理/參數(shù)/廠家-蛋白標(biāo)準(zhǔn)品-艾美捷科技有限公司

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背景資料: ILK1 （Integrin-linked kinase） is a serine/threonine protein kinase， containing 4 ankyrin-like repeats. ILK1 regulates a number of biological properties which include: anchorage-independent cell cycle progression， tumor cell invasion and apoptosis. ILK1 can also be implicated in mediating cell architecture， adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Furthermore， ILK1 phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues， but also AKT1 and GSK3B.
ILK1 interacts with the cytoplasmic domains of integrin ?1 and ?3 subunits in addition to several adaptors and signaling proteins， it also acts as a proximal receptor kinase regulating integrin-mediated signal transduction. ILK1 is a focal adhesion protein part of the complex ILK-PINCH. This complex is deemed to be one of the convergence points of integrin- and growth factor-signaling pathway. ILK1 is stimulated rapidly but briefly by both cell fibronectin interactions， as well as by insulin， in a PI3-K-dependent manner， probably through the binding of PtdIns（3，4，5）P3 with a PH-like domain of ILK.
ILK1 over-expression has been documented in a wide variety of human malignancies.

溶解建議: 提供的人整合素連接激酶（ILK1）產(chǎn)品為過(guò)濾滅菌的透明溶液；其中人整合素連接激酶（ILK1）產(chǎn)品溶解于1x PBS，50%甘油溶液中.

保存建議: 人整合素連接激酶（ILK1）溶液可以在4℃冷藏保存2-4周；如果想延長(zhǎng)保存時(shí)間，建議分裝后置于-20℃凍存.請(qǐng)避免反復(fù)凍融.

其他: ProSpec 是一家全球著名細(xì)胞因子蛋白生產(chǎn)和研發(fā)的公司，具有20多年的生產(chǎn)經(jīng)驗(yàn)，專注于蛋白（重組及合成）生產(chǎn)研發(fā)。我們的核心產(chǎn)品包括：干擾素、白介素、骨蛋白、腫瘤壞死因子、成纖維生長(zhǎng)因子、瘦素、干細(xì)胞因子、催乳素、表皮生長(zhǎng)因子、胰島素樣生長(zhǎng)因子、神經(jīng)生長(zhǎng)因子、集落刺激因子、激素、酶、病毒抗原以及各種重組蛋白等。領(lǐng)先的生產(chǎn)工藝和規(guī)模使其可以提供毫克到克級(jí)蛋白，價(jià)格優(yōu)于同類公司。絕大部分產(chǎn)品是天然成熟型蛋白，而不含有標(biāo)簽蛋白。考慮到大部分研究者希望能更靈活地配制蛋白溶液，ProSpec-Tany絕大部分產(chǎn)品沒(méi)有添加保護(hù)劑或鹽，這就對(duì)工藝提出了更高的要求。同時(shí)，ProSpec-Tany絕大部分產(chǎn)品為凍干粉，因此易于運(yùn)輸和保存。