CRYAB 一抗-CRYAB Primary antibody代理/參數(shù)/廠家-一抗-艾美捷科技有限公司

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中文名稱: CRYAB 一抗

英文名字: CRYAB Primary antibody

供應(yīng)商: Promab

產(chǎn)品貨號: PMB-20182

產(chǎn)品報價: ￥詢價/100ul

產(chǎn)品說明書: 點擊查看

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背景資料: Crystallin, alpha B. Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy.

應(yīng)用類型: IHC

免疫原: Purified recombinant fragment of CRYAB (aa1-175) expressed in E. Coli.

來源宿主: Mouse

反應(yīng)性: Human

保存建議: 4℃短期保存；-20℃長期保存。避免凍融循環(huán)。

其他: ProMab 生物技術(shù)公司通過整合生物信息學(xué)、分子生物學(xué)、蛋白質(zhì)表達、純化技術(shù)、基因克隆、微生物學(xué)和免疫學(xué)，利用新型高通量技術(shù)開發(fā)重組蛋白、抗體和工程細胞系并將其商業(yè)化。專注于免疫治療領(lǐng)域，特別是 CAR-T/NK 細胞技術(shù)。ProMab 還開發(fā)了一種新型的 mRNA 脂質(zhì)納米顆粒（mRNA-LNP）平臺，用于即用型試劑和定制研究服務(wù)，以推進現(xiàn)有產(chǎn)品并擴展到更多的研究領(lǐng)域。