FAS 一抗-FAS Primary antibody代理/參數(shù)/廠家-一抗-艾美捷科技有限公司

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背景資料: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.

其他: ProMab 生物技術公司通過整合生物信息學、分子生物學、蛋白質(zhì)表達、純化技術、基因克隆、微生物學和免疫學，利用新型高通量技術開發(fā)重組蛋白、抗體和工程細胞系并將其商業(yè)化。專注于免疫治療領域，特別是 CAR-T/NK 細胞技術。ProMab 還開發(fā)了一種新型的 mRNA 脂質(zhì)納米顆粒（mRNA-LNP）平臺，用于即用型試劑和定制研究服務，以推進現(xiàn)有產(chǎn)品并擴展到更多的研究領域。