Efalizumab Biosimilar uses the same protein sequences as the therapeutic antibody efalizumab.nnEfalizumab is a monoclonal anti-CD11a antibody used to treat moderate to severe plaque psoriasis.nnHumanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin.nnEfalizumab binds to CD11a, a subunit of leukocyte function antigen-1 (LFA-1), which is expressed on all leukocytes. As a result efalizumab decreases cell surface expression of CD11a.
應(yīng)用類型
Flow cytometry, animal model study
免疫原
Human CD11a
來源宿主
CHO cells
反應(yīng)性
Human
保存建議
Store at 4°C 1 month, store at -20°C to -70°C 12 month. protected from prolonged exposure to light. Avoid freeze/thaw cycles.