Muromonab Biosimilar uses the same protein sequences as the therapeutic antibody muromonab (OKT3).nnMuromonab (OKT-3) is a monoclonal anti-CD3 antibody used as immunosuppressive therapy in kidney, heart, and liver transplant patients.nnMurine monoclonal antibody specific to CD3 T-cell lymphocyte antigens. More specifically it is a purified murine (mouse) monoclonal antibody, directed against the CD3 (T3) receptor on the surface of human T-cells (T-lymphocytes) cultured using the murine ascites method. Muromonab is 93% monomeric immune globulin G type 2a (IgG2a).nnMuromonab binds to the T-cell surface glycoprotein CD3 epsilon chain. It appears to kill CD-3 positive cells by inducing Fc mediated apoptosis, antibody mediated cytotoxicity and complement-dependent cytotoxicity.
應用類型
Flow cytometry, animal model study
免疫原
Human CD3
來源宿主
CHO cells
反應性
Human
保存建議
Store at 4°C 1 month, store at -20°C to -70°C 12 month. protected from prolonged exposure to light. Avoid freeze/thaw cycles.
其他
cluster of differentiation 3, CD3D, CD3E, CD3G, OKT-3, OKT3