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中文名稱

Ramucirumab 生物類似藥, 人 VEGFR2 單克隆抗體

英文名字
Ramucirumab Biosimilar, Human VEGFR2 Monoclonal Antibody
供應(yīng)商
Promab
產(chǎn)品貨號
PMB-B00050
產(chǎn)品報價
¥詢價/1mg/5mg/20mg
產(chǎn)品說明書
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產(chǎn)品新聞
背景資料
What is ramucirumab biosimilar research grade? Research grade Ramucirumab biosimilar uses the same protein sequences as the therapeutic antibody ramucirumab. Ramucirumab, a fully human IgG1 monoclonal antibody and a direct VEGFR2 antagonist, binds with high affinity to the extracellular domain of VEGFR2 and block the binding of natural VEGFR ligands (VEGF-A, VEGF-C and VEGF-D). These ligands are secreted by solid tumors to promote angiogenesis (formation of new blood vessels from pre-existing ones) and enhance tumor blood supply. Binding of ramucirumab to VEGFR2 leads to inhibition of VEGF-mediated tumor angiogenesis.nnKinase insert domain receptor (KDR, a type IV receptor tyrosine kinase, CD309, cluster of differentiation 309, Flk1, Fetal Liver Kinase 1) is the human gene encoding vascular endothelial growth factor receptor 2 (VEGFR-2), which is a VEGF receptor. The Q472H germline KDR genetic variant affects VEGFR-2 phosphorylation and has been found to associate with microvessel density in NSCLC.
應(yīng)用類型
Flow cytometry, animal model study
免疫原
Human VEGFR2
來源宿主
CHO cells
反應(yīng)性
Human
保存建議
Store at 4°C 1 month, store at -20°C to -70°C 12 month. protected from prolonged exposure to light. Avoid freeze/thaw cycles.
其他
Anti-KDR Human Monoclonal Antibody, Ramucirumab Research Grade, Ramucirumab RUO
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