Isatuximab Biosimilar uses the same protein sequences as the therapeutic antibody isatuximab.nnIsatuximab is a humanized, IgG1-derived monoclonal antibody (mAb) produced from a Chinese hamster ovary (CHO) cell line. Structurally, isatuximab is comprised of two identical immunoglobulin kappa light chains and two identical immunoglobulin gamma heavy chains. It is a cytolytic antibody targeted against CD38, a glycoprotein found on the surface of some immune cells that is highly expressed by malignant plasma cells in multiple myeloma. Along with daratumumab, another anti-CD38 monoclonal antibody, isatuximab constitutes a novel treatment modality for patients with difficult-to-treat multiple myeloma.
應(yīng)用類(lèi)型
Flow cytometry, animal model study
免疫原
Human CD38
來(lái)源宿主
CHO cells
反應(yīng)性
Human
保存建議
Store at 4°C 1 month, store at -20°C to -70°C 12 month. protected from prolonged exposure to light. Avoid freeze/thaw cycles.
其他
cluster of differentiation 38, cyclic ADP ribose hydrolase, a paralog of CD157, ADPRC1, ADPRC 1