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中文名稱

重組鼠巨噬細胞炎性蛋白-1 γ/CCL 9/10(rMuCCL9/10)

英文名字
Recombinant Murine Macrophage Inflammatory Protein-1 gamma/ CCL9/10 (rMuCCL9/10)
供應(yīng)商
Bioworld
產(chǎn)品貨號
PR2028
產(chǎn)品報價
¥詢價/5ug
產(chǎn)品說明書
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產(chǎn)品新聞
背景資料
Macrophage Inflammatory Protein-1 gamma (MIP-1 gamma), also called MIP-2, belongs to the β (or CC) intercrine family of chemokines. It is further classified as a member of the NC6 or six cysteine-containing CC subfamily of chemokines. This subfamily contains four N-terminally extended chemokines, two human (CCL15 and CCL23) and two mouse (CCL9 and CCL10). Chemokines are known to undergo proteolytic processing to generate multiple isoforms. NC6 chemokines are usually only marginally active at full length, but are converted to highly active forms upon Nterminal truncation. Mature CCL9, in the presence of inflammatory fluids, is naturally truncated by 28, 29 or 30 aa at the N terminus, generating a highly active, 8 kDa, 71-73 aa CCR1 ligand. In contrast, other CCR1 ligands, CCL3/MIP1α and CCL5/RANTES, lose their potency when proteolytically processed. CCL9/10 is constitutively secreted, and circulates as a full length molecule. Any onset of inflammation with subsequent enzyme release may act on local NC6 chemokines, generating early, potent leukocyte chemoattractants.
序列
QITHATETKE VQSSLKAQQG LEIEMFHMGF QDSSDCCLSY NSRIQCSRFI GYFPTSGGCT RPGIIFISKR GFQVCANPSD RRVQRCIERL EQNSQPRTYK Q
來源宿主
Escherichia coli.
溶解建議
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <-20
保存建議
This lyophilized preparation is stable at 2-8
其他
Bioworld是專一服務(wù)于生命科學研究的專業(yè)技術(shù)型企業(yè),Bioworld品牌創(chuàng)立以來擁有10000多種常規(guī)產(chǎn)品現(xiàn)貨,現(xiàn)有8000多種現(xiàn)貨抗體,以及其他IVD原料,蛋白等現(xiàn)貨產(chǎn)品。在細胞信號通路、免疫學、蛋白組學上擁有顯著優(yōu)勢,其抗體產(chǎn)品、生長因子、IVD原料等為生命科學科研工作者提供了極大的便利
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