【泛素G76A】重組人泛素G76A突變-Recombinant Human Ubiquitin Gly76 to Ala76 mutation代理/參數(shù)/廠家-蛋白標準品-艾美捷科技有限公司

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背景資料: The conserved 76 amino acid protein ubiquitin （Ub） regulates a host of intracellular processes through its enzymatic conjugation to other cellular proteins.
Ubiquitination occurs through sequential steps catalyzed by activating （E1）， conjugating （E2）， and ligase （E3） enzymes. The final step results in the formation of an isopeptide bond between Ub’s C-terminal glycine residue （G76） and a lysine residue of the target protein， although N-terminal ubiquitination is also known.
Outcomes of this modification include destabilization of the conjugated protein， altered protein trafficking and functional modulation.
After targeting the protein for specific localizations， ubiquitin is released from the substrate by deubiquitinating enzymes.
A mutant ubiquitin， having a Gly to Ala substitution at the C-terminus （G76A ubiquitin） supported several downstream reactions of the proteolytic pathway but inhibits the deubiquitination process.
As consequence， the Ub derivative becomes irreversibly conjugated to protein， shifting the equilibrium between the bound and unbound form in the direction of conjugation， at the expense of the free form.

保存建議: Store vial at -20℃ to -80℃. When stored at the recommended temperature， this protein is stable for 12 months. Please prevent freeze-thaw cycles.

其他: ProSpec 是一家全球著名細胞因子蛋白生產(chǎn)和研發(fā)的公司，具有20多年的生產(chǎn)經(jīng)驗，專注于蛋白（重組及合成）生產(chǎn)研發(fā)。我們的核心產(chǎn)品包括：干擾素、白介素、骨蛋白、腫瘤壞死因子、成纖維生長因子、瘦素、干細胞因子、催乳素、表皮生長因子、胰島素樣生長因子、神經(jīng)生長因子、集落刺激因子、激素、酶、病毒抗原以及各種重組蛋白等。領先的生產(chǎn)工藝和規(guī)模使其可以提供毫克到克級蛋白，價格優(yōu)于同類公司。絕大部分產(chǎn)品是天然成熟型蛋白，而不含有標簽蛋白。考慮到大部分研究者希望能更靈活地配制蛋白溶液，ProSpec-Tany絕大部分產(chǎn)品沒有添加保護劑或鹽，這就對工藝提出了更高的要求。同時，ProSpec-Tany絕大部分產(chǎn)品為凍干粉，因此易于運輸和保存。