中文名稱

【p53】重組人p53

英文名字

Recombinant Human BolA Homolog 1

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ProSpec

產(chǎn)品貨號

PRO-302

產(chǎn)品報價

￥詢價/1mg   ￥20ug   ￥5ug

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產(chǎn)品新聞

背景資料

Tumor protein p53 responds to various cellular stresses by regulating target genes that induce cell cycle arrest， apoptosis， senescence， DNA repair， or changes in metabolism. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth， replication， and apoptosis. p53 is a DNA-binding protein containing transcription activation， DNA-binding & oligomerization domains.
p53 binds to mdm2， SV40 T antigen and human papilloma virus E6 protein p53 senses DNA damage and possibly facilitating repair. p53 protein is a transcription factor which is encoded in humans by the TP53 gene. Alterations of TP53 occur not only as somatic mutations in human malignancies， but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. p53 mutants that often occur in many different human cancers fail to bind the consensus DNA binding site， and hence cause the loss of tumor suppressor activity. Mutation involving p53 is found in a wide variety of malignant tumors， including breast， ovarian， bladder， colon， lung， and melanoma. The p53 expression in normal cells is low and in an assortment of transformed cell lines is high， which may contribute to transformation and malignancy. Multiple p53 variants encode distinct isoforms， which can regulate p53 transcriptional activity. p53’s significance in multicellular organisms is in cell cycle regulation therefore it functions as a tumor suppressor that is involved in preventing cancer. p53’s role in conserving stability by preventing genome mutation has earned it descriptions such as "the guardian of the genome，" "the guardian angel gene，" and the "master watchman.” The name p53 refers to its evident molecular mass: it migrates as a 53kDa protein on SDS-PAGE. However， based on calculations from its amino acid residues， p53’s mass is in fact only 43.7kDa. This difference is attributed to the high number of proline residues in the protein which slow its migration on SDS-PAGE， consequently making it appear larger than it actually is.

序列

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來源宿主

大腸桿菌中重組表達(dá)

溶解建議

Sterile Filtered clear solution. Purified human p53 in 20mM Tris， pH 8， 0.6M Nacl and 50% Glycerol.

保存建議

For long term storage store at -20℃. Avoid freeze/thaw cycles.

其他

ProSpec 是一家全球著名細(xì)胞因子蛋白生產(chǎn)和研發(fā)的公司，具有20多年的生產(chǎn)經(jīng)驗(yàn)，專注于蛋白（重組及合成）生產(chǎn)研發(fā)。我們的核心產(chǎn)品包括：干擾素、白介素、骨蛋白、腫瘤壞死因子、成纖維生長因子、瘦素、干細(xì)胞因子、催乳素、表皮生長因子、胰島素樣生長因子、神經(jīng)生長因子、集落刺激因子、激素、酶、病毒抗原以及各種重組蛋白等。 領(lǐng)先的生產(chǎn)工藝和規(guī)模使其可以提供毫克到克級蛋白，價格優(yōu)于同類公司。絕大部分產(chǎn)品是天然成熟型蛋白，而不含有標(biāo)簽蛋白。考慮到大部分研究者希望能更靈活地配制蛋白溶液，ProSpec-Tany絕大部分產(chǎn)品沒有添加保護(hù)劑或鹽，這就對工藝提出了更高的要求。同時，ProSpec-Tany絕大部分產(chǎn)品為凍干粉，因此易于運(yùn)輸和保存。

注意

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