TRIM21 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The 52 kDa Ro protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. Ro/SSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Ribonucleoprotein particle is composed of a single polypeptide and one of four small RNA molecules. The RoSSA is present in all mammalian cells studied but has no known function. At least 2 isoforms are present in nucleated and red blood cells, and tissue specific differences in Ro/SSA proteins were identified.
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來源宿主
大腸桿菌中重組表達
溶解建議
Sterile Filtered clear solution. The protein solution contains 6M Urea, 500mM NaCl and 10mM Tris pH8.0.
保存建議
Lyophilized RO-52 although stable at 4℃ for 3 weeks, should be stored desiccated below -18℃.
Please prevent freeze-thaw cycles.