中文名稱(chēng)

【因子VIIa】重組人凝血因子VIIa

英文名字

Recombinant Human Coagulation Factor VIIa

供應(yīng)商

ProSpec

產(chǎn)品貨號(hào)

PRO-331

產(chǎn)品報(bào)價(jià)

￥詢(xún)價(jià)/10ug   ￥1mg   ￥50ug

產(chǎn)品說(shuō)明書(shū)

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產(chǎn)品新聞

背景資料

Coagulation factor VII is a vitamin K-dependent factor which is essential for hemostasis. It circulates in the blood as a zymogen which is later converted to an active form by factor IXa， factor Xa， factor XIIa， or thrombin by minor proteolysis. Upon activation of factor VII， a heavy chain with a catalytic domain and a light chain with 2 EGF-like domains are generated， and the two chains are held together by a disulfide bond. The presence of factor III and calcium ions further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Alternative splicing of factor VII results in 2 transcripts. Defects in coagulation factor VII can cause coagulopathy. Coagulation factor VII initiates the extrinsic pathway of blood coagulation. Minor proteolysis converts factor VII to factor VIIa by factors Xa， XIIa， IXa， or thrombin. Factor VIIa also converts factor IX to factor IXa in the presence of tissue factor and calcium.

序列

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來(lái)源宿主

幼年倉(cāng)鼠腎細(xì)胞BHK細(xì)胞中重組表達(dá)

溶解建議

Sterile Filtered White lyophilized （freeze-dried） powder. The protein 1 mg/ml was lyophilized after from a sterile solution containing 4.86 mg sodium chloride， 2.45 mg calcium chloride dihydrate， 50 mg mannitol and 116 ug Tween 80. It is recommended to reconstitute the lyophilized Factor-VIIa in sterile 18MΩ-cm H2O not less than 100ug/ml， which can then be further diluted to other aqueous solutions.

保存建議

Lyophilized Factor-VIIa although stable at room temperature for 3 weeks， should be stored desiccated below -18℃. Upon reconstitution Factor-VIIa should be stored at 4℃ between 2-7 days and for future use below -18℃. Please prevent freeze-thaw cycles.

其他

ProSpec 是一家全球著名細(xì)胞因子蛋白生產(chǎn)和研發(fā)的公司，具有20多年的生產(chǎn)經(jīng)驗(yàn)，專(zhuān)注于蛋白（重組及合成）生產(chǎn)研發(fā)。我們的核心產(chǎn)品包括：干擾素、白介素、骨蛋白、腫瘤壞死因子、成纖維生長(zhǎng)因子、瘦素、干細(xì)胞因子、催乳素、表皮生長(zhǎng)因子、胰島素樣生長(zhǎng)因子、神經(jīng)生長(zhǎng)因子、集落刺激因子、激素、酶、病毒抗原以及各種重組蛋白等。 領(lǐng)先的生產(chǎn)工藝和規(guī)模使其可以提供毫克到克級(jí)蛋白，價(jià)格優(yōu)于同類(lèi)公司。絕大部分產(chǎn)品是天然成熟型蛋白，而不含有標(biāo)簽蛋白。考慮到大部分研究者希望能更靈活地配制蛋白溶液，ProSpec-Tany絕大部分產(chǎn)品沒(méi)有添加保護(hù)劑或鹽，這就對(duì)工藝提出了更高的要求。同時(shí)，ProSpec-Tany絕大部分產(chǎn)品為凍干粉，因此易于運(yùn)輸和保存。

注意

該頁(yè)面的中文產(chǎn)品信息的翻譯，僅供參考。準(zhǔn)確的產(chǎn)品信息請(qǐng)以廠家的英文說(shuō)明書(shū)為準(zhǔn)。下單前，請(qǐng)瀏覽說(shuō)明書(shū)確認(rèn)。

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