中文名稱

【因子IX】人凝血因子IX

英文名字

Human Coagulation Factor IX

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ProSpec

產(chǎn)品貨號

PRO-353

產(chǎn)品報價

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產(chǎn)品新聞

背景資料

Human Factor IX also called Christmas-Factor is a glycoprotein， which is synthesized in the liver and belongs to the serine proteases system and is part of the S1 peptidase family.
Lack of Factor-IX causes Hemophilia-B meaning Christmas Disease. Factor-IX has a N-terminus region which contains 12xGla residues which asist the calcium dpendant binding of Factor-IX to the phospholipid surface. Factor-IX is activated by either factor XIa or the factor VIIa/tissue factor/phospholipid complex. Cleavage yields the intermediate IXa， which is subsequently converted to the fully active form IXab.
Factor-IX binds initially to exosites on the factor XIa heavy chain， followed by interaction at the active site with subsequent bond cleavage. Coagulation factor IX is activated by interaction with the erythrocyte membrane， causing intrinsic coagulation. Chaperones & lectins act simultaniously to guarantee the proper folding of Factor-IX and the retention of mutant molecules. Human Factor IX， activated by either the Contact or Tissue Factor Pathway， is responsible for the activation of Factor X to Xa.

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來源宿主

人血漿中提取純化

溶解建議

Sterile Filtered White lyophilized （freeze-dried） powder. The Factor-IX was lyophilized from a sterile solution containing 20mM Tris-HCl pH-7.4， 0.1M NaCl and 1mM Benzamidine. It is recommended to reconstitute the lyophilized 100U Factor-IX in sterile 100ul of 18MΩ-cm H2O， which can then be further diluted to other aqueous solutions.

保存建議

Lyophilized Factor-IX although stable at room temperature for 3 weeks， should be stored desiccated below -18℃. Upon reconstitution Factor-IX should be stored at 4℃ between 2-7 days and for future use below -18℃. Please prevent freeze-thaw cycles.

其他

ProSpec 是一家全球著名細(xì)胞因子蛋白生產(chǎn)和研發(fā)的公司，具有20多年的生產(chǎn)經(jīng)驗(yàn)，專注于蛋白（重組及合成）生產(chǎn)研發(fā)。我們的核心產(chǎn)品包括：干擾素、白介素、骨蛋白、腫瘤壞死因子、成纖維生長因子、瘦素、干細(xì)胞因子、催乳素、表皮生長因子、胰島素樣生長因子、神經(jīng)生長因子、集落刺激因子、激素、酶、病毒抗原以及各種重組蛋白等。 領(lǐng)先的生產(chǎn)工藝和規(guī)模使其可以提供毫克到克級蛋白，價格優(yōu)于同類公司。絕大部分產(chǎn)品是天然成熟型蛋白，而不含有標(biāo)簽蛋白。考慮到大部分研究者希望能更靈活地配制蛋白溶液，ProSpec-Tany絕大部分產(chǎn)品沒有添加保護(hù)劑或鹽，這就對工藝提出了更高的要求。同時，ProSpec-Tany絕大部分產(chǎn)品為凍干粉，因此易于運(yùn)輸和保存。

注意

該頁面的中文產(chǎn)品信息的翻譯，僅供參考。準(zhǔn)確的產(chǎn)品信息請以廠家的英文說明書為準(zhǔn)。下單前，請瀏覽說明書確認(rèn)。

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