中文名稱(chēng)

【PEX】重組人C末端血紅素結(jié)合蛋白樣域MMP-2

英文名字

Recombinant Human C-terminal hemopexin-like domain of MMP-2 （445-635 a.a.）

供應(yīng)商

ProSpec

產(chǎn)品貨號(hào)

PRO-360

產(chǎn)品報(bào)價(jià)

￥已停產(chǎn)

產(chǎn)品說(shuō)明書(shū)

點(diǎn)擊查看

購(gòu)買(mǎi)方式

在線支付寶及網(wǎng)銀支付、支票、現(xiàn)金、電匯，或撥打全國(guó)免費(fèi)服務(wù)電話4006800868與我們聯(lián)系.

產(chǎn)品新聞

背景資料

Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity and can inhibit cell associated collagenolytic activity both in vitro and in vivo.
Moreover， PEX can block angiogenesis and tumor growth in vivo， providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis， but when administered in sufficient quantities， may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors and the cell surface， and is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX， which interferes with the cell membrane activation of MMP-2， reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3.

序列

請(qǐng)咨詢我們客服或者請(qǐng)查看品牌官方網(wǎng)站

來(lái)源宿主

大腸桿菌中重組表達(dá)

溶解建議

Sterile Filtered White lyophilized （freeze-dried） powder. The protein was lyophilized with 2mM Tris pH-7.4. It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100ug/ml， which can then be further diluted to other aqueous solutions.

保存建議

Lyophilized PEX although stable at room temperature for 3 weeks， should be stored desiccated below -18℃. Upon reconstitution PEX should be stored at 4℃ between 2-7 days and for future use below -18℃. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles.

其他

ProSpec 是一家全球著名細(xì)胞因子蛋白生產(chǎn)和研發(fā)的公司，具有20多年的生產(chǎn)經(jīng)驗(yàn)，專(zhuān)注于蛋白（重組及合成）生產(chǎn)研發(fā)。我們的核心產(chǎn)品包括：干擾素、白介素、骨蛋白、腫瘤壞死因子、成纖維生長(zhǎng)因子、瘦素、干細(xì)胞因子、催乳素、表皮生長(zhǎng)因子、胰島素樣生長(zhǎng)因子、神經(jīng)生長(zhǎng)因子、集落刺激因子、激素、酶、病毒抗原以及各種重組蛋白等。 領(lǐng)先的生產(chǎn)工藝和規(guī)模使其可以提供毫克到克級(jí)蛋白，價(jià)格優(yōu)于同類(lèi)公司。絕大部分產(chǎn)品是天然成熟型蛋白，而不含有標(biāo)簽蛋白。考慮到大部分研究者希望能更靈活地配制蛋白溶液，ProSpec-Tany絕大部分產(chǎn)品沒(méi)有添加保護(hù)劑或鹽，這就對(duì)工藝提出了更高的要求。同時(shí)，ProSpec-Tany絕大部分產(chǎn)品為凍干粉，因此易于運(yùn)輸和保存。

注意

該頁(yè)面的中文產(chǎn)品信息的翻譯，僅供參考。準(zhǔn)確的產(chǎn)品信息請(qǐng)以廠家的英文說(shuō)明書(shū)為準(zhǔn)。下單前，請(qǐng)瀏覽說(shuō)明書(shū)確認(rèn)。

分享到：