中文名稱

【B2GP1】重組人β2糖蛋白I

英文名字

Recombinant Human Apolipoprotein-H, Sf9

供應商

ProSpec

產品貨號

PRO-388

產品報價

￥詢價/1mg   ￥20ug   ￥5ug

產品說明書

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購買方式

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產品新聞

背景資料

?2 Glycoprotein I （?2 GP I） is a serum protein with a single polypeptide chain consisting of 326 amino acids and having a molecular weight of 50 kDa. The protein is also known by the alternative name Apolipoprotein H （ApoH） which gives an indication of its phospholipid binding function.
Since the detection of ?2 Glycoprotein I as a target of antiphospholipid antibodies in 1990 the discussion about the clinical relevance of ?2 GP I is still controversial. It is well established that anticardiolipin antibodies are a very heterogeneous group and that ?2 GP I is only one of several potential targets for anticardiolipin antibodies. Nevertheless it is generally accepted that the binding of ?2 GP I to anionic lipids or surface is essential for the differential detection of anticardiolipin antibodies associated with autoimmune diseases （versus those associated with infectious diseases like syphilis， tuberculosis， AIDS， etc）.
The close relationship of ?2 GP I antibodies and cardiolipin antibodies may indicate that the ?2 GP I isotypes have the same clinical relevance as the cardiolipin isotypes， where IgM， IgG and IgA autoantibodies have been observed and are routinely determined diagnostic targets.
B2GP1 antibodies and anticardiolipin antibodies can be detected in patients with arterial and venous thrombosis， recurrent fetal loss， thrombosis and SLE. The titers of anticardiolipin and anti-?2 GP I antibodies usually fluctuate sufficiently that they cannot be used for disease monitoring.

序列

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來源宿主

昆蟲Sf9細胞中重組表達

溶解建議

Sterile Filtered clear solution. B2GP1 is supplied in 16mM HEPES buffer pH-7.2， 200mM NaCl， and 20% glycerol.

保存建議

Store at 4℃ if entire vial will be used within 2-4 weeks. Store， frozen at -20℃ for longer periods of time. Avoid multiple freeze-thaw cycles.

其他

ProSpec 是一家全球著名細胞因子蛋白生產和研發(fā)的公司，具有20多年的生產經驗，專注于蛋白（重組及合成）生產研發(fā)。我們的核心產品包括：干擾素、白介素、骨蛋白、腫瘤壞死因子、成纖維生長因子、瘦素、干細胞因子、催乳素、表皮生長因子、胰島素樣生長因子、神經生長因子、集落刺激因子、激素、酶、病毒抗原以及各種重組蛋白等。 領先的生產工藝和規(guī)模使其可以提供毫克到克級蛋白，價格優(yōu)于同類公司。絕大部分產品是天然成熟型蛋白，而不含有標簽蛋白。考慮到大部分研究者希望能更靈活地配制蛋白溶液，ProSpec-Tany絕大部分產品沒有添加保護劑或鹽，這就對工藝提出了更高的要求。同時，ProSpec-Tany絕大部分產品為凍干粉，因此易于運輸和保存。

注意

該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。

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