中文名稱

【ZA2G】重組人鋅a2糖蛋白

英文名字

Recombinant Human Alpha-2-Glycoprotein 1 Zinc-Binding, HEK

供應(yīng)商

ProSpec

產(chǎn)品貨號(hào)

PRO-403

產(chǎn)品報(bào)價(jià)

￥詢價(jià)/100ug   ￥10ug   ￥2ug

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產(chǎn)品新聞

背景資料

Zinc-alpha-2-glycoprotein （ZAG） is found in body fluids such as serum， sweat， and seminal and breast cyst fluids. It is identical in amino acid sequence to tumor-derived lipid mobilizing factor （LMF）， a protein associated with the dramatic loss of adipose body stores in cancer cachexia， and has been shown to stimulate lipolysis by adipocytes in vivo and in vitro. A role for ZAG has been proposed in the regulation of body weight， and age-dependent changes in genetically influenced obesity， and also it regulates melanin production by normal and malignant melanocytes. It has also recently been classified as a novel adipokine in that it is produced by both white and brown fat adipocytes and may act in a local autocrine fashion in the reduction of adiposity in cachexia. Controlling ZAG/LMF’s activity could be life-saving in the management of certain cancers and other cachexiainducing conditions， and its possible normal role in body fat store homeostasis is deserving of understanding in its own right. ZAG exhibits a class I major histocompatibility complex （MHC） fold but is a soluble protein rather than being anchored to plasma membranes and does not associate with alpha-2-microglobulin in humans. Like antigen-presenting MHC class I proteins， ZAG has an open apical groove， and X-ray crystallography of human derived ZAG revealed an unidentifiable electron density in a similar position to that occupied by antigenic peptides in classical MHC proteins and glycolipids in isoforms of CD1. This presumptive ligand is not a peptide， and the groove is too small to hold a glycolipid such as is presented by CD1 isoforms. By analogy with all other MHC class I-related proteins that have an open apical groove [some do not ]， occupancy by a ligand is probably crucial to ZAG’s biological function. Despite all of the structural and biochemical evidence that ZAG binds a ligand， none has so far been found by extraction from protein isolated from biological fluids. This difficulty could be because the ligand is labile， heterogeneous， or readily lost during purification procedures. Knowing more about how ZAG interacts with the compounds it has been found to bind， both natural and artificial， will inform searches for the elusive ligand（s） and its/their role in ZAG’s signaling function.

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來(lái)源宿主

HEK293人胚腎上皮細(xì)胞中重組表達(dá)

溶解建議

Filtered White lyophilized （freeze-dried） powder. Filtered （0.4 um） and lyophilized in 0.5 mg/ml in 0.1M Tris-HCl pH 8.0 and 150mM NaCl. Add deionized water to a working concentration approximately 0.5 mg/ml and let the lyophilized pellet dissolve completely.

保存建議

Lyophilized ZA2G although stable at room temperature for 3 weeks， should be stored desiccated below -18℃. Upon reconstitution ZA2G should be stored at 4℃ between 2-7 days and for future use below -18℃. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please avoid freeze-thaw cycles.

其他

ProSpec 是一家全球著名細(xì)胞因子蛋白生產(chǎn)和研發(fā)的公司，具有20多年的生產(chǎn)經(jīng)驗(yàn)，專注于蛋白（重組及合成）生產(chǎn)研發(fā)。我們的核心產(chǎn)品包括：干擾素、白介素、骨蛋白、腫瘤壞死因子、成纖維生長(zhǎng)因子、瘦素、干細(xì)胞因子、催乳素、表皮生長(zhǎng)因子、胰島素樣生長(zhǎng)因子、神經(jīng)生長(zhǎng)因子、集落刺激因子、激素、酶、病毒抗原以及各種重組蛋白等。 領(lǐng)先的生產(chǎn)工藝和規(guī)模使其可以提供毫克到克級(jí)蛋白，價(jià)格優(yōu)于同類公司。絕大部分產(chǎn)品是天然成熟型蛋白，而不含有標(biāo)簽蛋白。考慮到大部分研究者希望能更靈活地配制蛋白溶液，ProSpec-Tany絕大部分產(chǎn)品沒(méi)有添加保護(hù)劑或鹽，這就對(duì)工藝提出了更高的要求。同時(shí)，ProSpec-Tany絕大部分產(chǎn)品為凍干粉，因此易于運(yùn)輸和保存。

注意

該頁(yè)面的中文產(chǎn)品信息的翻譯，僅供參考。準(zhǔn)確的產(chǎn)品信息請(qǐng)以廠家的英文說(shuō)明書為準(zhǔn)。下單前，請(qǐng)瀏覽說(shuō)明書確認(rèn)。

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