【Spectrin alpha】重組人血影蛋白a-Recombinant Human BPI fold containing family A Member 1代理/參數(shù)/廠家-蛋白標(biāo)準(zhǔn)品-艾美捷科技有限公司

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背景資料: Erythrocyte spectrin is the main component of the red cell membrane skeleton responsible for the shape and physical properties of red cells. SPTA1 is a member of the alpha-spectrin gene family. Spectrin is composed of 2 subunits a and b （280 and 246 kDa respectively）. The human erithroid a-spectrin （2418 amino acids） consists of 22 repeating segments of about 106 amino acids in length. SPTA1 forms weaker tetramer interactions than non-erythrocytic alpha spectrin， which may increase the plasma membrane elasticity and deformability of red blood cells. This protein was demonstrated to be a specific substrate for ubiquitination in vitro and in vivo. The main ubiquitination site on human a-spectrin was identified in the lysine 27 of the repeating segment 17 by site directed mutagenesis. Cell-free experiments using radiolabeled， biotinylated or native ubiquitin and cellular lysates from rabbit retyculocytes， human erythrocytes or k562 cells， showed that only monoubiquitination occurs at this site. Mutations in the SPTA1 gene result in a variety of hereditary red blood cell disorders， such as elliptocytosis type 2， pyropoikilocytosis， and spherocytic hemolytic anemia.

溶解建議: Sterile Filtered clear solution. The protein （1.7mg/ml） contains 50mM Tris buffer pH-8 and 10mM glutathione.

保存建議: GST-alpha Spectrin although stable at 4℃ for 1 week， should be stored desiccated below -18℃. Please prevent freeze-thaw cycles.

其他: ProSpec 是一家全球著名細(xì)胞因子蛋白生產(chǎn)和研發(fā)的公司，具有20多年的生產(chǎn)經(jīng)驗，專注于蛋白（重組及合成）生產(chǎn)研發(fā)。我們的核心產(chǎn)品包括：干擾素、白介素、骨蛋白、腫瘤壞死因子、成纖維生長因子、瘦素、干細(xì)胞因子、催乳素、表皮生長因子、胰島素樣生長因子、神經(jīng)生長因子、集落刺激因子、激素、酶、病毒抗原以及各種重組蛋白等。領(lǐng)先的生產(chǎn)工藝和規(guī)模使其可以提供毫克到克級蛋白，價格優(yōu)于同類公司。絕大部分產(chǎn)品是天然成熟型蛋白，而不含有標(biāo)簽蛋白。考慮到大部分研究者希望能更靈活地配制蛋白溶液，ProSpec-Tany絕大部分產(chǎn)品沒有添加保護劑或鹽，這就對工藝提出了更高的要求。同時，ProSpec-Tany絕大部分產(chǎn)品為凍干粉，因此易于運輸和保存。