中文名稱(chēng)

【REG3A】重組人淀粉重組蛋白3a

英文名字

Recombinant Human Regenerating Islet-Derived 3 Alpha

供應(yīng)商

ProSpec

產(chǎn)品貨號(hào)

PRO-421

產(chǎn)品報(bào)價(jià)

￥詢(xún)價(jià)/10ug   ￥1mg   ￥2ug

產(chǎn)品說(shuō)明書(shū)

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產(chǎn)品新聞

背景資料

Pancreatitis-associated protein （PAP） is a secretory protein not normally expressed in healthy pancreas but highly induced during acute pancreatitis. While PAP has been shown to be anti-bacterial and antiapoptotic in vitro， its definitive biological function in vivo is not clear. Using antisepse oligonucleotides， inhibition of PAP expression significantly worsened pancreatitis in a rat model. During pancreatitis， PAP released by the pancreas could mediate lung inflammation through induction of hepatic TNF- alpha expression and subsequent increase in circulating TNF-alpha.
PAP is activated in primary liver cancers. In normal liver， the protein is undetectable in normal mature hepatocytes and found only in some ductular cells， representing potential hepatic progenitor cells. PAP can be considered hepatic cytokine that combines mitogenic and anti-apoptotic functions regarding hepatocytes， and consequently acts as a growth factor in vivo to enhance liver regeneration. In pancreatic cancor， PAP was overexpressed in 79% （30 of 38） of pancreatic ductal adenocarcinoma， 19% （7 of 36） of chronic pancreatitis， and 29% （2 of 7） of mucinous cystadenoma. PAP was found in malignant ductular structures in pancreatic carcinomas as well as in benign proliferating ductules and acinar cells in chronic pancreatitis. Elevation of PAP in patients with pancreatic cancer is not merely explainable by concomitant pancreatitis， but seems to be due to increased PAP production by the cancer cells and is also correlated to tumour load as expressed by the UICC stages.
Epithelial expression of PAP was induced under intestinal mucosal inflammation initiated by exposure to commensal bacteria or DSS as well as inflamed IBD colon. Increased serum level of PAP diagnosed ileal location in active Crohn disease with a sensitivity of 60%， a specificity of 94%， a positive predictive value of 84% and a negative predictive value of 81%. Elevated serum PAP （> 50 ng/mL） is significantly associated with disease activity and ileal location of Crohn disease.

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來(lái)源宿主

大腸桿菌中重組表達(dá)

溶解建議

Filtered White lyophilized （freeze-dried） powder. Filtered （0.4um） and lyophilized from 0.5 mg/ml in 0.05M Acetate buffer pH-4. It is recommended to add 0.1M Acetate buffer pH-4 to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. For conversion into higher pH value， we recommend intensive dilution by relevant buffer to a concentration of 10ug/ml. In higher concentrations the solubility of this antigen is limited. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.

保存建議

Store lyophilized protein at -20℃. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4℃ for a limited period of time； it does not show any change after two weeks at 4℃. The lyophilized protein remains stable until the expiry date when stored at -20℃.

其他

ProSpec 是一家全球著名細(xì)胞因子蛋白生產(chǎn)和研發(fā)的公司，具有20多年的生產(chǎn)經(jīng)驗(yàn)，專(zhuān)注于蛋白（重組及合成）生產(chǎn)研發(fā)。我們的核心產(chǎn)品包括：干擾素、白介素、骨蛋白、腫瘤壞死因子、成纖維生長(zhǎng)因子、瘦素、干細(xì)胞因子、催乳素、表皮生長(zhǎng)因子、胰島素樣生長(zhǎng)因子、神經(jīng)生長(zhǎng)因子、集落刺激因子、激素、酶、病毒抗原以及各種重組蛋白等。 領(lǐng)先的生產(chǎn)工藝和規(guī)模使其可以提供毫克到克級(jí)蛋白，價(jià)格優(yōu)于同類(lèi)公司。絕大部分產(chǎn)品是天然成熟型蛋白，而不含有標(biāo)簽蛋白。考慮到大部分研究者希望能更靈活地配制蛋白溶液，ProSpec-Tany絕大部分產(chǎn)品沒(méi)有添加保護(hù)劑或鹽，這就對(duì)工藝提出了更高的要求。同時(shí)，ProSpec-Tany絕大部分產(chǎn)品為凍干粉，因此易于運(yùn)輸和保存。

注意

該頁(yè)面的中文產(chǎn)品信息的翻譯，僅供參考。準(zhǔn)確的產(chǎn)品信息請(qǐng)以廠家的英文說(shuō)明書(shū)為準(zhǔn)。下單前，請(qǐng)瀏覽說(shuō)明書(shū)確認(rèn)。

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