中文名稱(chēng)

【REG4】重組人淀粉重組蛋白4

英文名字

Recombinant Human Regenerating Islet-Derived 4

供應(yīng)商

ProSpec

產(chǎn)品貨號(hào)

PRO-424

產(chǎn)品報(bào)價(jià)

￥詢(xún)價(jià)/10ug   ￥1mg   ￥2ug

產(chǎn)品說(shuō)明書(shū)

點(diǎn)擊查看

購(gòu)買(mǎi)方式

在線(xiàn)支付寶及網(wǎng)銀支付、支票、現(xiàn)金、電匯，或撥打全國(guó)免費(fèi)服務(wù)電話(huà)4006800868與我們聯(lián)系.

產(chǎn)品新聞

背景資料

REG protein was shown to be stimulated during the regeneration of pancreatic islets. Since then， many Reg-related proteins have been identified in humans and other animals. In human， the four REG family genes， i.e.， REG 1 alpha， REG 1 beta， REG-related sequence （RS） and HIP/PAP， have so far been isolated. These Reg-related proteins are classified into four subfamilies according to their amino-acid sequences， but they share a similar structure and physiological function. Reg protein is a growth factor for pancreatic beta cells and also suggests that the administration of Reg protein could be used as another therapeutic approach for diabetes mellitus. Human REG cDNA which encodes a 166-amino acid protein with a 22-amino acid signal peptide. The amino acid sequence of human REG protein has 68% homology to that of rat Reg protein.
Reg I was found to be expressed mainly in pancreatic beta and acinoductular cells as well as gastric fundic enterochromaffin-like （ECL） cells. Reg I production in ECL cells is stimulated by gastrin， as well as by the proinflammatory cytokine， cytokine-induced neutrophil chemoattractant （CINC）-2Beta. In patients with chronic hypergastrinemia， Reg production is stimulated， with the increased proliferation of gastric mucosal cells. Patients with Helicobacter pylori infection also showed increased Reg production in the gastric mucosa， partly via increased plasma gastrin concentration and partly via increased proinflammatory cytokine production. The serum concentration of the reg-protein was significantly higher in patients with various pancreatic diseases than in normal controls， and was also significantly higher in patients with acute pancreatitis or chronic relapsing pancreatitis than in patients with chronic pancreatitis. Furthermore， the serum PSP/reg-protein concentration was also significantly increased in liver cirrhosis， choledocholithiasis， and various cancers of the digestive system.

序列

請(qǐng)咨詢(xún)我們客服或者請(qǐng)查看品牌官方網(wǎng)站

來(lái)源宿主

大腸桿菌中重組表達(dá)

溶解建議

Filtered （0.4um） and lyophilized from 0.5 mg/ml in 20mM Tris， pH 8.0. Add deionized water to a working concentration approximately 0.5 mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by appropriate sterile filter before using it in the cell culture.

保存建議

Store lyophilized protein at -20℃. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4℃ for a limited period of time； it does not show any change after two weeks at 4℃. The lyophilized protein remains stable until the expiry date when stored at -20℃.

其他

ProSpec 是一家全球著名細(xì)胞因子蛋白生產(chǎn)和研發(fā)的公司，具有20多年的生產(chǎn)經(jīng)驗(yàn)，專(zhuān)注于蛋白（重組及合成）生產(chǎn)研發(fā)。我們的核心產(chǎn)品包括：干擾素、白介素、骨蛋白、腫瘤壞死因子、成纖維生長(zhǎng)因子、瘦素、干細(xì)胞因子、催乳素、表皮生長(zhǎng)因子、胰島素樣生長(zhǎng)因子、神經(jīng)生長(zhǎng)因子、集落刺激因子、激素、酶、病毒抗原以及各種重組蛋白等。 領(lǐng)先的生產(chǎn)工藝和規(guī)模使其可以提供毫克到克級(jí)蛋白，價(jià)格優(yōu)于同類(lèi)公司。絕大部分產(chǎn)品是天然成熟型蛋白，而不含有標(biāo)簽蛋白。考慮到大部分研究者希望能更靈活地配制蛋白溶液，ProSpec-Tany絕大部分產(chǎn)品沒(méi)有添加保護(hù)劑或鹽，這就對(duì)工藝提出了更高的要求。同時(shí)，ProSpec-Tany絕大部分產(chǎn)品為凍干粉，因此易于運(yùn)輸和保存。

注意

該頁(yè)面的中文產(chǎn)品信息的翻譯，僅供參考。準(zhǔn)確的產(chǎn)品信息請(qǐng)以廠(chǎng)家的英文說(shuō)明書(shū)為準(zhǔn)。下單前，請(qǐng)瀏覽說(shuō)明書(shū)確認(rèn)。

分享到：