【PM / Scl 100】重組人PM / Scl100蛋白-Recombinant Human Exosome Component 10代理/參數(shù)/廠家-蛋白標準品-艾美捷科技有限公司

PRODUCT CENTER

蛋白標準品

產(chǎn)品中心

當前位置：首頁 > 產(chǎn)品中心 > 細胞生物學產(chǎn)品 > 蛋白標準品

背景資料: PM/Scl 100 is a nucleolar protein and represents one crucial component of the so-called "PM/Scl complex" or "nuclear exosome"， which is an RNA-processing complex consisting of a number of exoribonucleases （not to be confused with certain multivesicular bodies which are shed by cultured cells into the culture fluid and are also called exosomes）.
Autoantibodies against PM/Scl 100 occur in patients suffering from polymyositis， scleroderma or polymyositis/scleroderma overlap syndromes. While antibodies to other components of the exosome complex （PM/Scl 75， several Rrp proteins） can be found in some sera， practically all patients with autoantibodies against the PM/Scl complex are positive for PM/Scl 100 antibodies， making this specificity an important marker. The presence of PM/Scl 100 autoantibodies is a comparatively "good" prognostic sign in polymyositis/scleroderma overlap syndrome unlike the poor prognosis seen when other myositis and systemic sclerosis specific autoantibodies are present.

溶解建議: Sterile Filtered clear solution. PM/Scl 100is supplied at a concentration of 0.8mg/ml in 20mM HEPES， pH-7.5， 100mM NaCl， 0.01mM EDTA， 0.02% SDS.

保存建議: Store at 4℃ if entire vial will be used within 2-4 weeks. Store， frozen at -20℃ for longer periods of time. Avoid multiple freeze-thaw cycles.

其他: ProSpec 是一家全球著名細胞因子蛋白生產(chǎn)和研發(fā)的公司，具有20多年的生產(chǎn)經(jīng)驗，專注于蛋白（重組及合成）生產(chǎn)研發(fā)。我們的核心產(chǎn)品包括：干擾素、白介素、骨蛋白、腫瘤壞死因子、成纖維生長因子、瘦素、干細胞因子、催乳素、表皮生長因子、胰島素樣生長因子、神經(jīng)生長因子、集落刺激因子、激素、酶、病毒抗原以及各種重組蛋白等。領(lǐng)先的生產(chǎn)工藝和規(guī)模使其可以提供毫克到克級蛋白，價格優(yōu)于同類公司。絕大部分產(chǎn)品是天然成熟型蛋白，而不含有標簽蛋白。考慮到大部分研究者希望能更靈活地配制蛋白溶液，ProSpec-Tany絕大部分產(chǎn)品沒有添加保護劑或鹽，這就對工藝提出了更高的要求。同時，ProSpec-Tany絕大部分產(chǎn)品為凍干粉，因此易于運輸和保存。