中文名稱

【因子VIII RA】重組人凝血因子VIII相關(guān)抗原

英文名字

Recombinant Human Melanoma Antigen Family A, 3

供應(yīng)商

ProSpec

產(chǎn)品貨號

PRO-502

產(chǎn)品報價

￥詢價/10ug   ￥1mg   ￥2ug

產(chǎn)品說明書

點擊查看

購買方式

在線支付寶及網(wǎng)銀支付、支票、現(xiàn)金、電匯，或撥打全國免費服務(wù)電話4006800868與我們聯(lián)系.

產(chǎn)品新聞

背景資料

Factor VIII related antigen or von Willebrand factor is a multimeric glycoprotein. It has functional binding domains to platelet glycoprotein Ib， glycoprotein IIb/IIIa， collagen and heparin. von Willebrand factor is synthesized by endothelial cells and stored in the Weibel-Palade granules. It mediates platelet adhesion to injured vessel walls and serves as a carrier and stabilizer for coagulation factor VIII. von Willebrand factor is one of the most useful markers to identify endothelial （or megakaryocytic） lineage of neoplasms. As not all endothelial cells synthesize / store） this molecule， about 30% of tumors of vascular origin fail to stain for factor VIII related antigen， regardless of whether they are benign or malignant. Staining for factor VIII related antigen has also been used to measure angiogenesis， an indicator of tumor recurrence. vWF functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. vWF is critical to the hemostasis process. vWF is deficient or defective in von Willebrand disease and is involved in a large number of other diseases， including thrombotic thrombocytopenic purpura， Heyde’s syndrome， and possibly hemolytic-uremic syndrome.
vWF is produced constitutively in the endothelium （in the Weibel-Palade bodies）， in the megakaryocytes （?-granules of platelets）， and in the subendothelial connective tissue. Since Von Willebrand factor is not an enzyme it has no catalytic activity. vWF’s principal function is binding to other proteins， mainly to Factor VIII and it is essential in platelet adhesion to wound sites. Factor VIII is attached to vWF while inactive in the circulation. Factor VIII degrades quickly when not attached to vWF.

序列

請咨詢我們客服或者請查看品牌官方網(wǎng)站

來源宿主

大腸桿菌中重組表達(dá)

溶解建議

Sterile Filtered clear solution. Factor VIII Related Antigen in 50mM Tris-Acetate， pH7.5， 1mM EDTA and 20% Glycerol.

保存建議

Store vial at -20℃ to -80℃. When stored at the recommended temperature， this protein is stable for 12 months. Please prevent freeze-thaw cycles.

其他

ProSpec 是一家全球著名細(xì)胞因子蛋白生產(chǎn)和研發(fā)的公司，具有20多年的生產(chǎn)經(jīng)驗，專注于蛋白（重組及合成）生產(chǎn)研發(fā)。我們的核心產(chǎn)品包括：干擾素、白介素、骨蛋白、腫瘤壞死因子、成纖維生長因子、瘦素、干細(xì)胞因子、催乳素、表皮生長因子、胰島素樣生長因子、神經(jīng)生長因子、集落刺激因子、激素、酶、病毒抗原以及各種重組蛋白等。 領(lǐng)先的生產(chǎn)工藝和規(guī)模使其可以提供毫克到克級蛋白，價格優(yōu)于同類公司。絕大部分產(chǎn)品是天然成熟型蛋白，而不含有標(biāo)簽蛋白。考慮到大部分研究者希望能更靈活地配制蛋白溶液，ProSpec-Tany絕大部分產(chǎn)品沒有添加保護(hù)劑或鹽，這就對工藝提出了更高的要求。同時，ProSpec-Tany絕大部分產(chǎn)品為凍干粉，因此易于運輸和保存。

注意

該頁面的中文產(chǎn)品信息的翻譯，僅供參考。準(zhǔn)確的產(chǎn)品信息請以廠家的英文說明書為準(zhǔn)。下單前，請瀏覽說明書確認(rèn)。

分享到：