MITF is a basic helix-loop-helix-leucin zipper (b-HLH-ZIP) transtripotion factor implicated in pigmentation, mast cells and bone development. The mutation of MITF causes Waardenburg Syndrome type II and Tietz syndrome in humans. In mice, a profound loss of pigmented cells in the skin eye and inner ear results, as well as osteopetrosis and defects in natural killer and mast cells. There are two known isoforms of MITF differing by 66 amino acids at the NH2 terminus. Shorter forms are expressed in melanocytes and run as two bands at 52kDa and 56kDa, while the longer MITF form runs as a cluster of bands at 60-70kDa in osteoclasts and in B16 melonoma cells (but not other melanoma cell lines), as well as mast cells and heart.
序列
請(qǐng)咨詢我們客服或者請(qǐng)查看品牌官方網(wǎng)站
來(lái)源宿主
大腸桿菌中重組表達(dá)
溶解建議
Sterile Filtered clear solution. MITF in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol.
保存建議
Store vial at -20℃ to -80℃. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles.