中文名稱

【A2M】人a-2巨球蛋白

英文名字

Human Alpha-2 Macroglobulin Protein

供應(yīng)商

ProSpec

產(chǎn)品貨號

PRO-551

產(chǎn)品報價

￥詢價/1mg   ￥200ug

產(chǎn)品說明書

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購買方式

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產(chǎn)品新聞

背景資料

Alpha-2 Macroglobulin is a serine proteases inhibitor， which inhibits coagulation by inactivating thrombin and Kallikrein， it inhibits fibrinolysis by inactivating plasmin and involved in insulin transport. Alpha-2-Macroglobulin is a large plasma protein， which is produced by the liver， it’s composed of 4 identical subunits bound together by -S-S- bonds. A2M is able to inactivate many kinds of proteinases （including serine-， cysteine-， aspartic- and metalloproteinases）. ?2M has a 35 amino acid "bait" region in its structure. Proteinases bind and cleave the “bait” region become bound to ?2M. Macrophage receptors recognize the proteinase-?2M complex and clear it from the system. A2M binds to and removes MMP-2 and MMP-9 （active forms of the gelatinase） from the circulation using scavenger receptors on the phagocytes. The levels of Alpha-2-macroglobulin are increased in nephrotic syndrome which is a condition where the kidneys start to leak out some of the smaller blood proteins. Due to its large size， ?2-macroglobulin is retained in the bloodstream. Increased production of all proteins causes ?2-macroglobulin concentration to increase. Chronic renal failure might lead to amyloid by alpha-2-macroglobulin. A2M is raised in cirrhosis， pregnancy and diabetes.

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來源宿主

人血漿中提取純化

溶解建議

Sterile Filtered White lyophilized （freeze-dried） powder. Lyophilized from 0.02M TRIS， 0.15M NaCl and 0.1M Sucrose， pH 8.0.

保存建議

Human Alpha-2 Macroglobulin although stable at room temperature for 3 weeks， should be stored between 2-8℃.

其他

ProSpec 是一家全球著名細(xì)胞因子蛋白生產(chǎn)和研發(fā)的公司，具有20多年的生產(chǎn)經(jīng)驗，專注于蛋白（重組及合成）生產(chǎn)研發(fā)。我們的核心產(chǎn)品包括：干擾素、白介素、骨蛋白、腫瘤壞死因子、成纖維生長因子、瘦素、干細(xì)胞因子、催乳素、表皮生長因子、胰島素樣生長因子、神經(jīng)生長因子、集落刺激因子、激素、酶、病毒抗原以及各種重組蛋白等。 領(lǐng)先的生產(chǎn)工藝和規(guī)模使其可以提供毫克到克級蛋白，價格優(yōu)于同類公司。絕大部分產(chǎn)品是天然成熟型蛋白，而不含有標(biāo)簽蛋白。考慮到大部分研究者希望能更靈活地配制蛋白溶液，ProSpec-Tany絕大部分產(chǎn)品沒有添加保護(hù)劑或鹽，這就對工藝提出了更高的要求。同時，ProSpec-Tany絕大部分產(chǎn)品為凍干粉，因此易于運(yùn)輸和保存。

注意

該頁面的中文產(chǎn)品信息的翻譯，僅供參考。準(zhǔn)確的產(chǎn)品信息請以廠家的英文說明書為準(zhǔn)。下單前，請瀏覽說明書確認(rèn)。

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