中文名稱

【肝珠蛋白】重組人結(jié)??合珠蛋白

英文名字

Recombinant Human Haptoglobin

供應(yīng)商

ProSpec

產(chǎn)品貨號

PRO-567

產(chǎn)品報(bào)價(jià)

￥詢價(jià)/1mg   ￥20ug   ￥5ug

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產(chǎn)品新聞

背景資料

Haptoglobin is a glycoprotein which is synthesized in the liver and circulates in the blood. Haptoglobin is produced typically by hepatocytes but also by other tissues: e.g. skin， lung， and kidney. It is a positive acute phase protein that binds free hemoglobin and removes it from the circulation to prevent kidney injury， and iron loss following hemolysis. The haptoglobin-hemoglobin complex is subsequently removed by the reticuloendothelial system （generally the spleen）. As the reticuloendothelial system removes the haptoglobin-hemoglobin complex from the body， haptoglobin levels are reduced in hemolytic anaemias. In the course of binding hemoglobin， haptoglobin sequesters the iron inside hemoglobin， preventing iron-utilizing bacteria from benefitting from hemolysis.
Haptoglobin consists of two ?- and two ?-chains， connected by disulfide bonds. Three major haptoglobin phenotypes are known to exist （Hp 1-1， Hp 2-1， and Hp 2-2）. Hp 1-1 is biologically the most effective in binding free hemoglobin and suppressing inflammatory responses associated with free hemoglobin. Hp 2-2 is biologically the least active， and Hp 2-1 is moderately active. Haptoglobin’s molecular mass ranges from 8-200 kDa.
Reduced levels can be seen in haemolysis and impaired liver function. High levels are a marker for acute or chronic inflammation. Ahaptoglobinemia or hypohaptoglobinemia are caused by mutations in the haptoglobin gene and/or its regulatory regions. Haptoglobin is also linked to diabetic nephropathy， the incidence of coronary artery disease in type 1 diabetes， Crohn’s disease， inflammatory disease behavior， primary sclerosing cholangitis， susceptibility to idiopathic Parkinson’s disease， and a reduced incidence of Plasmodium falciparum malaria.

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來源宿主

大腸桿菌中重組表達(dá)

溶解建議

Sterile Filtered White lyophilized （freeze-dried） powder. Each mg was lyophilized with 1xPBS， 0.1% SDS and 1mM DTT. It is recommended to reconstitute the lyophilized Haptoglobin in sterile 18MΩ-cm H2O not less than 100ug/ml， which can then be further diluted to other aqueous solutions.

保存建議

Lyophilized Haptoglobin although stable at room temperature for 3 weeks， should be stored desiccated below -18℃. Upon reconstitution Haptoglobin should be stored at 4℃ between 2-7 days and for future use below -18℃. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles.

其他

ProSpec 是一家全球著名細(xì)胞因子蛋白生產(chǎn)和研發(fā)的公司，具有20多年的生產(chǎn)經(jīng)驗(yàn)，專注于蛋白（重組及合成）生產(chǎn)研發(fā)。我們的核心產(chǎn)品包括：干擾素、白介素、骨蛋白、腫瘤壞死因子、成纖維生長因子、瘦素、干細(xì)胞因子、催乳素、表皮生長因子、胰島素樣生長因子、神經(jīng)生長因子、集落刺激因子、激素、酶、病毒抗原以及各種重組蛋白等。 領(lǐng)先的生產(chǎn)工藝和規(guī)模使其可以提供毫克到克級蛋白，價(jià)格優(yōu)于同類公司。絕大部分產(chǎn)品是天然成熟型蛋白，而不含有標(biāo)簽蛋白。考慮到大部分研究者希望能更靈活地配制蛋白溶液，ProSpec-Tany絕大部分產(chǎn)品沒有添加保護(hù)劑或鹽，這就對工藝提出了更高的要求。同時(shí)，ProSpec-Tany絕大部分產(chǎn)品為凍干粉，因此易于運(yùn)輸和保存。

注意

該頁面的中文產(chǎn)品信息的翻譯，僅供參考。準(zhǔn)確的產(chǎn)品信息請以廠家的英文說明書為準(zhǔn)。下單前，請瀏覽說明書確認(rèn)。

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