中文名稱

【PTTG1】重組人垂體瘤轉(zhuǎn)化蛋白1

英文名字

Recombinant Human Pituitary Tumor-Transforming Protein 1

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ProSpec

產(chǎn)品貨號(hào)

PRO-717

產(chǎn)品報(bào)價(jià)

￥詢價(jià)/1mg   ￥20ug   ￥5ug

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產(chǎn)品新聞

背景資料

PTTG1 （Securin） is mainly involved in the regulation of sister chromatid separation during cell division. Securin is a regulatory protein， which has a central role in chromosome stability， in the p53/TP53 pathway， and DNA repair. Additional two roles have been identified for PTTG1； the first one is to facilitate the transport of separase （cysteine protease） to the nucleus and the second role is to hinder the catalytic activity of separase. PTTG1 is ubiquitinated by the APC （Anaphase Promoting Complex）， and subsequently degraded by the Proteasome， releasing separase. During the mitosis， PTTG1 blocks Separase/ESPL1 function， thus preventing the proteolysis of the cohesin complex and the ensuing segregation of the chromosomes. However， PTTG1 function is not restricted to a blocking activity only， since it is required to activate ESPL1. PTTG1 is ubiquitinated at the beginning of anaphase， leading to its destruction and to the liberation of ESPL1.
PTTG1 contains two PXXP motifs， which are necessary for its transforming and tumorigenic activities， in addition to its stimulation of basic fibroblast growth factor expression. It also contains a D box （destruction box） which is essential for its degradation by the APC. The acidic C-terminal region of the Securin can function as a transactivation domain. Even though， PTTG1 is primarily a cytosolic protein， it partially localizes in the nucleus.
PTTG1 is highly expressed in various tumors； it also has transforming activity in vitro and tumorigenic activity in vivo. Furthermore， PTTG1 negatively regulates the transcriptional activity and related apoptosis activity of TP53.

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來源宿主

大腸桿菌中重組表達(dá)

溶解建議

Sterile Filtered colorless solution. The PTTG1 solution contains 20mM Tris-HCl buffer （pH8.0）， 0.1M NaCl and transforming gene 10% glycerol.

保存建議

PTTG1 although stable 4℃ for 4 weeks， should be stored desiccated below -18℃. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles.

其他

ProSpec 是一家全球著名細(xì)胞因子蛋白生產(chǎn)和研發(fā)的公司，具有20多年的生產(chǎn)經(jīng)驗(yàn)，專注于蛋白（重組及合成）生產(chǎn)研發(fā)。我們的核心產(chǎn)品包括：干擾素、白介素、骨蛋白、腫瘤壞死因子、成纖維生長(zhǎng)因子、瘦素、干細(xì)胞因子、催乳素、表皮生長(zhǎng)因子、胰島素樣生長(zhǎng)因子、神經(jīng)生長(zhǎng)因子、集落刺激因子、激素、酶、病毒抗原以及各種重組蛋白等。 領(lǐng)先的生產(chǎn)工藝和規(guī)模使其可以提供毫克到克級(jí)蛋白，價(jià)格優(yōu)于同類公司。絕大部分產(chǎn)品是天然成熟型蛋白，而不含有標(biāo)簽蛋白。考慮到大部分研究者希望能更靈活地配制蛋白溶液，ProSpec-Tany絕大部分產(chǎn)品沒有添加保護(hù)劑或鹽，這就對(duì)工藝提出了更高的要求。同時(shí)，ProSpec-Tany絕大部分產(chǎn)品為凍干粉，因此易于運(yùn)輸和保存。

注意

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