CRNN is part of the "fused gene" family of proteins, which enclose N-terminus EF-hand domains and multiple tandem peptide repeats. CRNN contains two EF-hand Ca2+ binding domains in its N-terminus and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. CRNN, also known as SEP53, which participates in the mucosal/epithelial immune response and epidermal differentiation. CRNN is a survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and discharge of calcium. When CRNN is over expressed in oral squamous carcinoma cell lines, it regulates negatively cell proliferation by the induction of G1 arrest.
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來源宿主
大腸桿菌中重組表達
溶解建議
Sterile Filtered clear colorless solution. The CRNN solution contains 20mM Tris-HCl pH-8 and 10% glycerol.
保存建議
CRNN Recombinant Human although stable at 4℃ for 30 days, should be stored desiccated below -20℃ for periods greater than 30 days. Please avoid freeze-thaw cycles.