SUB1 is a coactivator that functions together with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. SUB1 interacts with the activation domain of transcription factor IIA (TFIIA) and TATA-binding protein (TBP)-associated factors (TAFs) to directly bind to double stranded DNA. SUB1 induces both activation and repression of RNAPII basal transcription, depending on the presence or absence of these transcription factors and holoenzyme components.
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來源宿主
大腸桿菌中重組表達
溶解建議
Sterile filtered colorless solution. SUB1 Human solution containing 20mM Tris HCL pH-8, 0.2M NaCl, 5mM DTT & 20% glycerol.
保存建議
SUB1 Human although stable at 4℃ for 1 week, should be stored desiccated below -18℃. Please prevent freeze thaw cycles.