STAT 1, SAPK/JNK, S6 Ribosomal Protein, HSP27, phosphorylated, BioAssay Detection Kit discontinued-STAT 1, SAPK/JNK, S6 Ribosomal Protein, HSP27, phosphorylated, BioAssay Detection Kit discontinued代理/參數(shù)/廠家-細(xì)胞分析試劑盒-艾美捷科技有限公司

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中文名稱: STAT 1, SAPK/JNK, S6 Ribosomal Protein, HSP27, phosphorylated, BioAssay Detection Kit discontinued

英文名字: STAT 1, SAPK/JNK, S6 Ribosomal Protein, HSP27, phosphorylated, BioAssay Detection Kit discontinued

供應(yīng)商: USBiological

產(chǎn)品貨號(hào): S7969-04

產(chǎn)品報(bào)價(jià): ￥1/250ul

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產(chǎn)品描述: Stat1, while activated in response to a large number of ligands, appears to be essential for responsiveness to IFN-a and IFN-g (1–3). Phosphorylation of Stat1 at Tyr701 induces Stat1 dimerization, nuclear translocation and DNA binding (4). Stat1 has been found to be inappropriately activated in many tumors (5). The stress-activated protein kinase/Jun-terminal kinase SAPK/JNK is potently and preferentially activated by a variety of environmental stresses, including UV and g radiation, ceramides, inflammatory cytokines and, in some instances, by growth factors and GPCR agonists (6,7). SAPK/JNK, when active as a dimer, can translocate to the nucleus where it regulates transcription through its effects on c-Jun, ATF-2 and other transcription factors (8). To effectively promote growth and cell division in a sustained manner, growth factors and mitogens must upregulate translation (9,10). Growth factors and mitogens induce the activation of p70 S6 kinase, which in turn phosphorylate the S6 ribosomal protein. Phosphorylation of S6 correlates with an increase in translation, particularly of mRNAs with an oligopyrimidine tract in their 5' untranslated regions (10). This group of mRNAs (5'TOP) encodes proteins involved in cell cycle progression and proteins that are part of the translational machinery, such as ribosomal proteins and elongation factors (10,11). Heat shock protein (HSP) 27 is one of the small HSPs, regulated at both the transcriptional and posttranslational levels (12). In response to stress, the expression level of HSP27 increases several-fold to confer cellular resistance to the adverse environmental change. HSP27 is also phosphorylated at serines 15, 78 and 82 by MAPKAP kinase 2 as a result of p38 MAP kinase pathway activation (13,14).Applications: Suitable for use in ELISA and Western Blot. Other applications not tested.Recommended Dilution:Western blot 1:200Optimal dilutions to be determined by the researcher.Storage and Stability:May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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保存建議: 建議收到STAT 1, SAPK/JNK, S6 Ribosomal Protein, HSP27, phosphorylated, BioAssay Detection Kit discontinued產(chǎn)品后將其置于-20°C保存。

其他: Usbiological公司是美國(guó)著名的抗體和生化試劑供應(yīng)商，生產(chǎn)世界上種類最多的抗體，用于Western Blot、免疫沉淀、免疫熒光、免疫組化和流式細(xì)胞術(shù)等多種檢測(cè)方法。Usbiological公司現(xiàn)已擁有超過(guò)50,19234種抗體、抗原和生化產(chǎn)品，為科研用戶提供了諸多超值選擇。