中文名稱(chēng)

用于鑒定退化神經(jīng)元的Fluoro-Jade B（FJB）粉末

英文名字

Fluoro-Jade B (FJB) Powder for identifying Degenerating Neurons

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Biosensis

產(chǎn)品貨號(hào)

TR-150-FJB

產(chǎn)品報(bào)價(jià)

￥詢(xún)價(jià)/30mg

產(chǎn)品說(shuō)明書(shū)

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購(gòu)買(mǎi)方式

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產(chǎn)品新聞

背景資料

The causes and effects of neuronal degeneration are of major interest to a wide variety of neuroscientists. Paralleling this growing interest is an increasing number of methods applicable to the detection of neuronal degeneration. The fluorescent dye Fluoro-Jade B (FJB), like its more purified brother Fluoro-Jade C (FJC), is an anionic fluorescein derivative useful for the histological staining of neurons undergoing degeneration. Fluoro-Jade B differs from FJC in that it is a slightly less refined chemical formulation and thus it does not quite provide the same level of signal to noise or high resolution as FJC. Nonetheless FJB is still widely used and works very well as a marker of degenerating neurons and even glia (see Damjanac M et al.,?Brain Res.?2007;1128(1):40-9). FJB operates nearly identically in protocol to that of FJC, and Fluoro-Jade B is compatible with several other labeling procedures including immunofluorescent and fluorescent Nissl techniques. Fluoro-Jade B stains all degenerating neurons regardless of specific insult or mechanism of cell death. Fluoro-Jade B exhibits the greatest signal to background ratio, as well as the highest resolution. This translates to a stain of maximal contrast and affinity for degenerating neurons. This makes it ideal for localising not only degenerating nerve cell bodies but also distal dendrites, axons and terminals. The dye is highly resistant to fading and is compatible with virtually all histological processing and staining protocols.

產(chǎn)品描述

熒光染料Fluoro-Jade B（FJB）與Fluoro-Jade C（FJC）是一種陰離子熒光素衍生物，可用于變性神經(jīng)元的組織學(xué)染色。FJB與FJC的不同之處在于，它的化學(xué)配方比FJC略遜一籌（FJC純度更高），因此無(wú)法提供與FJC相同的信噪比或高分辨率。盡管如此，F(xiàn)JB仍被廣泛使用，并且可以很好地用作退化神經(jīng)元甚至神經(jīng)膠質(zhì)細(xì)胞的有效標(biāo)記物。FJB的操作流程與FJC幾乎相同，并且Fluoro-Jade B與其他幾種標(biāo)記程序兼容，包括免疫熒光和Nissl熒光技術(shù)

產(chǎn)品形式

Dry, Coffee brown to brick red powder; hygroscopic powder keep dessicated.

保存建議

收到該用于鑒定退化神經(jīng)元的Fluoro-Jade B（FJB）粉末產(chǎn)品后，請(qǐng)按照產(chǎn)品說(shuō)明書(shū)的建議保存條件保存。

其他

Biosensis專(zhuān)注于神經(jīng)科學(xué)領(lǐng)域的抗體和試劑的開(kāi)發(fā)，特別是神經(jīng)營(yíng)養(yǎng)因子和神經(jīng)營(yíng)養(yǎng)因子受體。 近30年來(lái)，Biosensis一直是該領(lǐng)域的全球領(lǐng)航者和OEM供應(yīng)商。除神經(jīng)營(yíng)養(yǎng)因子，我們的神經(jīng)科學(xué)產(chǎn)品組合還被廣泛用于神經(jīng)退行性疾病、神經(jīng)發(fā)育和神經(jīng)代謝的研究。重點(diǎn)研究領(lǐng)域包括阿爾茨海默氏癥（AD）、帕金森氏癥（PD）和肌萎縮側(cè)索硬化（ALS）疾病，以及自噬和代謝應(yīng)激障礙，包括肥胖、代謝綜合征的研究、神經(jīng)免疫學(xué)和炎癥。Biosensis的產(chǎn)品系列不僅包括持續(xù)增長(zhǎng)的神經(jīng)科學(xué)研究抗體系列，還包括200多種定量研究ELISAs試劑盒（1板或2板，自由選擇），組織染色（退化神經(jīng)元染色試劑盒、病理髓鞘染色試劑盒、淀粉樣斑塊染色試劑等）和細(xì)胞可視化試劑（染色）以及針對(duì)神經(jīng)科學(xué)和細(xì)胞疾病研究的純化的蛋白質(zhì)。我們的抗體和試劑已被廣泛應(yīng)用于各種技術(shù)，包括蛋白質(zhì)印跡，免疫組織化學(xué)，流式分析，共聚焦顯微鏡實(shí)時(shí)成像，生物抑制和細(xì)胞培養(yǎng)以及克隆。

注意

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