中文名稱

S5a 蛋白(人) (GST標(biāo)簽)

英文名字

S5a protein(human) (GST-tag)

供應(yīng)商

Viva Bioscience

產(chǎn)品貨號

VB2284-100

產(chǎn)品報(bào)價(jià)

￥3250/100ug

產(chǎn)品說明書

點(diǎn)擊查看

購買方式

產(chǎn)品新聞

背景資料

S5a, also known as PSMD4, is a major ubiquitin binding protein that binds preferentially to polyubiquitin chains. It is found as a non-ATPase subunit of the 19S regulatory complex of the 26S proteasome where it functions as a receptor for proteins destined for proteolytic degradation. In yeast, the homologue of S5a, Rpn10, is required for degradation of a subset of cellular proteins by the proteasome. Unlike other proteasome subunits, S5a exists predominantly as a free protein in the cytosol (i.e. not incorporated into the proteasome), though its precise role in the cytosol has yet to be fully elucidated.

S5a contains two approximately 15 amino acid ubiquitin interacting motifs (UIM) which are responsible for its binding to polyubiquitin chains. In vitro S5a binds predominantly to chains of at least four ubiquitins in length and can act as a substrate for a wide range of ubiquitin E3 ligases, which, it has been suggested, occurs by a novel mechanism involving the association of S5a with growing poly-Ub chains.

Recombinant human S5a protein expressed with a N-terminal GST-tag. Protein has utility in ubiquitin binding assays.

序列

P55036

來源宿主

溶解建議

1 mg/mL

保存建議

其他

?

注意

該頁面的中文產(chǎn)品信息的翻譯，僅供參考。準(zhǔn)確的產(chǎn)品信息請以廠家的英文說明書為準(zhǔn)。下單前，請瀏覽說明書確認(rèn)。

分享到：