- 中文名稱
UbcH6 蛋白(人) (His標(biāo)簽)
- 英文名字
- UbcH6 protein(human) (His tag)
- 供應(yīng)商
- Viva Bioscience
- 產(chǎn)品貨號(hào)
- VB2480-100
- 產(chǎn)品報(bào)價(jià)
- ￥3250/100ug
- 產(chǎn)品說明書
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- 背景資料
- UbcH6, also known as UBE2E1, is a member of the ubiquitin E2 conjugating enzyme family, essential components of the ubiquitin cascade.
The selectivity of the ubiquitin cascade for a particular substrate protein relies on the interaction between the E2 conjugating enzyme (of which a cell contains relatively few) and an ubiquitin E3 ligase, of which over 600 have been identified to date. The specific E2-E3 pair required for ubiquitination of a particular substrate protein in vivo may also control the type of ubiquitin modification (mono-, multi-, poly-ubiquitin), the exact substrate lysine residue(s) to be modified and, in the case of polyubiquitination, the chain length and lysine linkage type.
UbcH6 is a tumour suppressor candidate which also modulates the transcriptional repression activity of Ataxin-1, the gene product of Spinocerebellar ataxia type 1 (SCA1). SCA1 is an autosomal-dominant neurodegenerative disorder characterized by ataxia and progressive motor deterioration, which is caused by expansion of the polyglutamine tract in Ataxin-1. UbcH6 has also be shown to act as an E2 conjugating enzyme for ISG15.
Recombinant human UbcH6 protein expressed with a N-terminal His-tag. Protein has utility in ubiquitination reactions, polyubiquitin chain synthesis, identification of substrate specific E2-E3 pairs and determination of E2 polyubiquitin linkage specificity.
- 序列
- P51965
- 來源宿主
- 溶解建議
- 1 mg/mL
- 保存建議
- 其他
- ?
- 注意
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