中文名稱

UbcH1 蛋白(人) (GST標(biāo)簽)

英文名字

UbcH1 protein(human) (GST tag)

供應(yīng)商

Viva Bioscience

產(chǎn)品貨號(hào)

VB2518-100

產(chǎn)品報(bào)價(jià)

￥3250/100ug

產(chǎn)品說(shuō)明書(shū)

點(diǎn)擊查看

購(gòu)買方式

產(chǎn)品新聞

背景資料

UbcH1, also known as UBE2K, is a member of the ubiquitin E2 conjugating enzyme family, essential components of the ubiquitin cascade.

The selectivity of the ubiquitin cascade for a particular substrate protein relies on the interaction between the E2 conjugating enzyme (of which a cell contains relatively few) and an ubiquitin E3 ligase, of which over 600 have been identified to date. The specific E2-E3 pair required for ubiquitination of a particular substrate protein in vivo may also control the type of ubiquitin modification (mono-, multi-, poly-ubiquitin), the exact substrate lysine residue(s) to be modified and, in the case of polyubiquitination, the chain length and lysine linkage type.

UbcH1 binds directly to the BRCA1 RING motif and is active with BRCA1-BARD1 in in vitro auto-ubiquitination assays. UbcH1 directs the synthesis of K63- or K48-linked ubiquitin chains on BRCA1 and can be utilised in the in vitro synthesis of unanchored K48-linked polyubiquitin chains. Malfunction of the ubiquitin-proteasome system in Alzheimer

序列

P61086

來(lái)源宿主

溶解建議

1 mg/mL

保存建議

其他

?

注意

該頁(yè)面的中文產(chǎn)品信息的翻譯，僅供參考。準(zhǔn)確的產(chǎn)品信息請(qǐng)以廠家的英文說(shuō)明書(shū)為準(zhǔn)。下單前，請(qǐng)瀏覽說(shuō)明書(shū)確認(rèn)。

分享到：